613-37-6
Chemical Structure
4-Methoxybiphenyl
- CAS No.: 613-37-6
- Formula:C13H12O
- Molecular Weight:184.24
IUPAC Name: 4-methoxy-1,1'-biphenyl
InChIKey: RHDYQUZYHZWTCI-UHFFFAOYSA-N
SMILES: COC1=CC=C(C=C1)C2=CC=CC=C2
Biological Activity: 4-Methoxybiphenyl is a cytochrome P450-dependent microsomal monooxygenase system substrate and metabolite precursor. 4-Methoxybiphenyl undergoes O-demethylation to generate 4-hydroxybiphenyl. 4-Methoxybiphenyl undergoes sulphation and glucuronidation conjugation; inhibition of sulphation shifts metabolism toward increased glucuronidation and unconjugated 4-hydroxybiphenyl accumulation. 4-Methoxybiphenyl serves as a model substrate for studying phase II metabolic conjugation pathway balance in rat isolated hepatocytes[1].
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4-Methoxybiphenyl | 4-Methoxybiphenyl is a cytochrome P450-dependent microsomal monooxygenase system substrate and metabolite precursor. 4-Methoxybiphenyl undergoes O-demethylation to generate 4-hydroxybiphenyl. 4-Methoxybiphenyl undergoes sulphation and glucuronidation conjugation; inhibition of sulphation shifts metabolism toward increased glucuronidation and unconjugated 4-hydroxybiphenyl accumulation. 4-Methoxybiphenyl serves as a model substrate for studying phase II metabolic conjugation pathway balance in rat isolated hepatocytes. | |||||||||||||||||||||
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- [1]. Fry JR, et al. Influence of the sulphation inhibitor, 2,6-dichloro-4-nitrophenol, on the production and conjugation, of 4-hydroxybiphenyl generated from 4-methoxybiphenyl by rat isolated hepatocytes. Biochem Pharmacol. 1987 Sep 15;36(18):3090-2. doi: 10.1016/0006-2952(87)90232-2. [Content Brief]
Keywords
