ACC2-IN-1
ACC2-IN-1 is an orally active, selective inhibitor of acetyl-CoA carboxylase 2 (ACC2), with an IC50 of 1.9 nM against human targets. ACC2-IN-1 acts as a reducing agent to decrease malonyl-CoA levels in skeletal muscle and exhibits a favorable CYP450 inhibition profile. ACC2-IN-1 can be used in the research of type 2 diabetes.
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- CAS No.: 2237229-78-4
- Formule: C20H20ClN3O3S
- Masse moléculaire:417.91
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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Chemical Information
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Activité biologique
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CYP2C19 18 μM (IC50) |
CYP2C9 13 μM (IC50) |
ACC2-IN-1 (compound 2e) potently inhibits human ACC2 with an IC50 of 1.9 nM and is 1026-fold selective over human ACC1[1].
ACC2-IN-1 (30 min) exhibits high metabolic stability, with 91% and 100% remaining after incubation in human and rat liver microsomes, respectively[1].
ACC2-IN-1 has an acceptable CYP450 inhibition profile, with no inhibition of CYP1A2, CYP2D6, or CYP3A4 at concentrations up to 20 μM, and IC50 values of 18 μM for CYP2C19 and 13 μM for CYP2C9[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6[1]
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Dosage:1.0 mg/kg; 2.5 mg/kg
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Administration:p.o.; single dose
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Result:Reduced skeletal muscle malonyl-CoA levels by 20%.
Reduced skeletal muscle malonyl-CoA levels by 41%.
Achieved corresponding plasma drug levels of 1130 ng/mL and 2621 ng/mL for the 1.0 mg/kg and 2.5 mg/kg doses, respectively.
Chemical Information
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CAS No. 2237229-78-4
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Masse moléculaire 417.91
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Formule C20H20ClN3O3S
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SMILES
ClC1=C2C(N=C(S2)OCC)=CC=C1OC3=CC=C(C=N3)/C=C/[C@H](C)NC(C)=O
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ACC2-IN-1 Related Classifications
HY-183919 Related Classifications
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