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Cat. No.: HY-123448

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CCG-120304

CCG-120304 is a TonB system inhibitor and bacteriostatic agent. CCG-120304 inhibits TonB-dependent functions. CCG-120304 is applicable to research related to urinary tract infections.

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CAS No.: 854005-84-8
Formule: C₁₉H₁₈O₃
Masse moléculaire:294.35

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Please store the product under the recommended conditions in the Certificate of Analysis.

CCG-120304 Chemical Structure

CAS No.: 854005-84-8

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Description

CCG-120304 is a TonB system inhibitor and bacteriostatic agent. CCG-120304 inhibits TonB-dependent functions. CCG-120304 is applicable to research related to urinary tract infections^[1].

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In Vitro

CCG-120304 (0.39-100 μM; 16-20 h) inhibits growth of UPEC CFT073 ΔtolC::kan under iron-limiting conditions with an AC₅₀ of 11 μM, acts as a bacteriostatic agent without disrupting proton motive force, and its inhibitory effect is reversed by excess iron^[1].
CCG-120304 (0.39-100 μM; 16 h) specifically targets the TonB system in UPEC, as its growth inhibitory activity is abrogated in TonB-deficient strains and reversed by TonB overexpression^[1].
CCG-120304 (100 μM; 20 min) inhibits TonB-dependent function in E. coli, as demonstrated by its ability to block irreversible adsorption of the TonB-dependent bacteriophage λh₈₀ without affecting TonB-independent phage adsorption^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 854005-84-8
Masse moléculaire 294.35
Formule C₁₉H₁₈O₃
SMILES

O=C1C(O)=C(OC2=CC=C(C=C21)C)C=3C=CC(=CC3)C(C)C
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Yep A, et al. Inhibitors of TonB function identified by a high-throughput screen for inhibitors of iron acquisition in uropathogenic Escherichia coli CFT073. mBio. 2014;5(2):e01089-13. Published 2014 Feb 25. [Content Brief]

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CCG-120304

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