ddATP trisodium solution (100 mM)
Based on 1 publication(s) in Google Scholar
ddATP (2',3'-Dideoxyadenosine 5'-triphosphate) trisodium, an active metabolite of 2',3'-dideoxyinosine, is a chain-elongating inhibitor of DNA polymerase. ddATP trisodium can be used for Sanger method for DNA sequencing and research of virus infection.
Nos produits utilisent uniquement pour la recherche. Nous ne vendons pas aux patients.
- Pureté: 99.93%
- CAS No.: 72029-21-1
- Formule: C10H13N5Na3O11P3
- Masse moléculaire:541.13
-
Stockage:
Solution, -20°C, 2 years
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
-
Activité biologique
-
Chemical Information
- Pureté et documentation
- Références
-
Help & FAQs
Publications Citing Use of MedChemExpress (MCE) ddATP trisodium solution (100 mM)
MoreVoir tous les produits spécifiques à Isoform DNA/RNA Synthesis
More
Activité biologique
|
DNA Polymerase |
ddATP (0.05-50 μM, 30 min) trisodium inhibits adenovirus DNA synthesis in isolated nuclei from adenovirus-infected KB cells[1].
ddATP (100 μM, 5 h) trisodium reduces the number of γH2A.X foci in the DSB (DNA double-strand breaks) oocytes[3].
ddATP trisodium inhibits HIV replication by inhibiting HIV reverse transcriptase[5].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:DSB oocytes
-
Concentration:100 μM
-
Incubation Time:5 h
-
Result:Suppressed the mtDNA replication without fully suppressed the nuclear DNA replication.
Chemical Information
-
CAS No. 72029-21-1
-
Appearance Liquid
-
Masse moléculaire 541.13
-
Formule C10H13N5Na3O11P3
-
Color Colorless to light yellow
-
SMILES
NC1=NC=NC2=C1N=CN2[C@H]3CC[C@H](O3)COP(OP(OP(O)(O[Na])=O)(O[Na])=O)(O[Na])=O
-
Synonyms
2',3'-Dideoxyadenosine 5'-triphosphate trisodium
-
Livraison
Room temperature in continental US; may vary elsewhere.
-
Stockage
Solution, -20°C, 2 years
Publications (1)
-
Journal Impact Factor
-
Most Recent
-
RNA
Improved precision, sensitivity, and adaptability of Ordered Two-Template Relay cDNA library preparation for RNA sequencing. [Abstract]2024 Dec 3:rna.080318.124. PMID: 39626888
Pureté et documentation
-
Fiche technique (276 KB)
-
SDS (252 KB)
- English - EN (252 KB)
- Français - FR (252 KB)
- Deutsch - DE (252 KB)
- Norwegian - NO (252 KB)
- Español - ES (252 KB)
- Swedish - SV (252 KB)
- Italian - IT (252 KB)
- Korean - KR (252 KB)
- Portuguese - PT (252 KB)
-
Instruction de manipulation (2659 KB)
Références
[1]. van der Vliet PC, et al. Role of DNA polymerase gamma in adenovirus DNA replication. Mechanism of inhibition by 2',3'-dideoxynucleoside 5'-triphosphates. Biochemistry. 1981 Apr 28;20(9):2628-32. [Content Brief]
[2]. Xu Lan, et al. Simultaneous determination of 2 ,3 -dideoxyinosine and the active metabolite, 2 ,3 -dideoxyadenosine-5 -triphosphate in human peripheral-blood mononuclear cell by HPLC–MS/MS and the application to cell pharmacokinetics. J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Oct 1;1002:337-42. [Content Brief]
[3]. Jun-Yu Ma, et al. Double-strand breaks induce short-scale DNA replication and damage amplification in the fully grown mouse oocytes. Genetics. 2021 Jun 24;218(2):iyab054. [Content Brief]
[4]. C M Perry, et al. Didanosine. An update on its antiviral activity, pharmacokinetic properties and therapeutic efficacy in the management of HIV disease. Drugs. 1996 Dec;52(6):928-62. [Content Brief]
[5]. Hao Z, et al. Factors determining the activity of 2',3'-dideoxynucleosides in suppressing human immunodeficiency virus in vitro. Mol Pharmacol. 1988 Oct;34(4):431-5. [Content Brief]
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
ddATP trisodium solution (100 mM) Related Classifications
HY-128036B Related Classifications
Powered by Bioz