DTX-P7
DTX-P7 is a peptide-drug conjugate. DTX-P7, composed of Docetaxel (DTX, HY-B0011) and a heptapeptide (P7), induces unfolded protein response and subsequent apoptosis by degrading Hsp90.
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- Formule: C84H118N8O25
- Masse moléculaire:1639.87
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| A549 | IC50 |
11.4 nM
|
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PMID: 35659720 |
| C3H/3T3 | IC50 |
11.4 nM
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PMID: 35659720 |
| H1975 | IC50 |
0.62 nM
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PMID: 35659720 |
| M21 | IC50 |
0.62 nM
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PMID: 35659720 |
DTX-P7 inhibits the expression of membrane Hsp90 in dose- and time-dependent manners, while no change in mRNA level is observed[1].
DTX-P7 enhances phosphorylation of PERK and eIF2α, whereas no XBP-1 RNA splicing is observed when A549 cells are exposed[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Chemical Information
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Masse moléculaire 1639.87
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Formule C84H118N8O25
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
DTX-P7 Related Classifications
HY-P10757 Related Classifications
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