JTB - jumping translocation breakpoint Gene

Also Known as PAR; hJT; HJTB; HSPC222

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 10899

About JTB

Cytogenetic location: 1q21.3 Genomic coordinates (GRCh38): 1:153,974,269-153,977,674 (from NCBI)

This gene has 6 transcripts (splice variants) and 197 orthologues. Ubiquitous expression in colon (RPKM 43.4), stomach (RPKM 38.7) and 25 other tissues.

Summary

Enables protein kinase binding activity. Involved in mitotic cytokinesis and positive regulation of protein kinase activity. Located in cytoplasm and midbody. Colocalizes with centrosome and spindle. [provided by Alliance of Genome Resources, Apr 2022]

JTB Products (1)

mRNA Protein Name
NM_006694.4 NP_006685.1 protein JTB precursor

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Références Source
enables protein kinase binding IDA
IDA: Inferred from direct assay
21225229 GOA
Biological Process GO Annotation Evidence Références Source
involved in mitotic cell cycle IMP
IMP: Inferred from mutant phenotype
21225229 GOA
involved in mitotic cytokinesis IMP
IMP: Inferred from mutant phenotype
21225229 GOA
involved in positive regulation of protein kinase activity IMP
IMP: Inferred from mutant phenotype
21225229 GOA
Cellular Component GO Annotation Evidence Références Source
colocalizes with centrosome IDA
IDA: Inferred from direct assay
21225229 GOA
located in cytoplasm IDA
IDA: Inferred from direct assay
21225229 GOA
located in midbody IDA
IDA: Inferred from direct assay
21225229 GOA
colocalizes with spindle IDA
IDA: Inferred from direct assay
21225229 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

JTB Protein Structure

JTB

JTB: Jumping translocation breakpoint protein (JTB) (30 - 143)

  • 0
  • 100
  • 146 a.a.
Protein Preferred Names Protein Names

protein JTB

  • jumping translocation breakpoint protein

Recombinant JTB Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75896 JTB Protein, Human (HEK293, Fc) O76095-1 (E31-L105) ≥ 90%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS07053 JTB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19863 Jtb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26362 Jtb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Mus musculus JTB MGD MGI:1346082
Rattus norvegicus JTB RGD RGD:2942