FRZB - frizzled related protein Gene

Also Known as FRE; OS1; FZRB; hFIZ; FRITZ; FRP-3; FRZB1; SFRP3; SRFP3; FRZB-1; FRZB-PEN

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 2487

About FRZB

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:182,833,275-182,866,637 (from NCBI)

This gene has 1 transcript (splice variant), 294 orthologues, 15 paralogues and is associated with 1 phenotype. Broad expression in spleen (RPKM 48.5), gall bladder (RPKM 25.9) and 20 other tissues.

Summary

The protein encoded by this gene is a secreted protein that is involved in the regulation of bone development. Defects in this gene are a cause of female-specific osteoarthritis (OA) susceptibility. [provided by RefSeq, Apr 2010]

FRZB Products (1)

mRNA Protein Name
NM_001463.4 NP_001454.2 secreted frizzled-related protein 3 precursor

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables protein binding IPI
IPI: Inferred from physical interaction
32296183 GOA
Biological Process GO Annotation Evidence Références Source
involved in negative regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
20208569 GOA
involved in negative regulation of canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
17471511 GOA
involved in negative regulation of cell growth IDA
IDA: Inferred from direct assay
20208569 GOA
involved in negative regulation of cell population proliferation IDA
IDA: Inferred from direct assay
20208569 GOA
acts upstream of or within positive regulation of apoptotic process IGI
IGI: Inferred from genetic interaction
18166153 GOA
acts upstream of or within positive regulation of fat cell differentiation IDA
IDA: Inferred from direct assay
12055200 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

FRZB Protein Structure

Fz

Fz: Fz domain (35 - 148)

NTR

NTR: UNC-6/NTR/C345C module (193 - 289)

  • 0
  • 100
  • 200
  • 300
  • 325 a.a.
Protein Preferred Names Protein Names

secreted frizzled-related protein 3

  • frezzled

FRZB Protein-protein interaction Information

Type
Protein Name Protein ID Interactor Interactor Species Interactor ID Detection Method Références
Intra
FRZB Q92765 CYSRT1 Homo sapiens A8MQ03
Y2H Prey Pooling
32296183
Intra
FRZB Q92765 CYSRT1 Homo sapiens A8MQ03
Y2H Array
32296183
Cross: Cross-species interaction Intra: Intraspecies interaction

Recombinant FRZB Proteins

Cat. No. Nom du produit Accession Pureté
HY-P75780 FRZB Protein, Human (HEK293, His) Q92765/NP_001454.2 (A32-N325) ≥ 85%, as determined by reducing SDS-PAGE.

Related Diseases

Diseases Alias
Osteoarthritis

  • Osteoarthrosis

  • Degenerative Joint Disease

  • Hypertrophic Arthritis

  • Arthropathy

  • Degenerative Polyarthritis

  • Degenerative Arthritis

  • Osteoarthrosis And Allied Disorder

  • Arthritis, Degenerative

  • Oa

  • Osteoarthritis Deformans

  • Osteoarthrosis Deformans

  • Kashin-Beck Disease
Holzgreve Syndrome

  • Holzgreve-Wagner-Rehder Syndrome

  • Holzgreve Wagner Rehder Syndrome

  • Complex Congenital Heart Defect, Renal Agenesis And Cleft Lip And Palate

  • Cleft Palate-Potter Sequence-Congenital Heart Anomalies-Mesoaxial Polydactyly-Multiple Malformations Syndrome
Monofixation Syndrome
Retinal Degeneration

  • Degeneration Of Retina
Localized Osteosarcoma

  • Localised Osteogenic Sarcoma

  • Localised Osteosarcoma

  • Localized Osteogenic Sarcoma
Hepatocellular Carcinoma

  • Liver Cancer

  • Primary Liver Cancer

  • HCC

  • Hepatoma

  • Malignant Neoplasm Of Liver

  • Liver Neoplasms

  • Cancer, Hepatocellular

  • Liver Cell Carcinoma

  • Lcc

  • Hepatoblastoma, Somatic

  • Hepatic Cancer

  • Primary Malignant Neoplasm Of Liver

  • Rare Tumor Of Liver And Intrahepatic Biliary Tract

  • Hepatocellular Carcinoma, Somatic

  • Hepatocellular Carcinoma, Childhood Type, Somatic

  • Hepatocellular Cancer, Somatic

  • Ca Liver - Primary

  • Hepatic Neoplasm

  • Malignant Hepato-Biliary Neoplasm

  • Malignant Neoplasm Of Liver, Not Specified As Primary Or Secondary

  • Malignant Neoplasm Of Liver, Primary

  • Malignant Tumor Of Liver

  • Neoplasm Of Liver

  • Non-Resectable Primary Hepatic Malignant Neoplasm

  • Resectable Malignant Neoplasm Of Liver

  • Resectable Malignant Neoplasm Of The Liver

  • Primary Liver Carcinoma

  • Primary Malignant Liver Neoplasm

  • Primary Cancer Of Liver

  • Primary Tumor Of The Liver

  • Rare Tumor Of Liver And Ibt

  • Hepatocellular Cancer

  • Neoplasm Of The Liver

  • Carcinoma, Hepatocellular

  • Hepatomas

  • Liver Neoplasm

  • Liver Carcinoma

  • Liver And Intrahepatic Biliary Tract Carcinoma

  • Malignant Hepatobiliary Neoplasm

  • Adult Primary Hepatocellular Carcinoma

  • Hepatoblastoma

  • Carcinoma Of Liver

  • Malignant Liver Tumour

  • Malignant Hepatic Tumour
Sclerosteosis

  • Cortical Hyperostosis With Syndactyly

  • Sost

  • Cortical Hyperostosis-Syndactyly Syndrome
Van Buchem Disease

  • Hyperostosis Corticalis Generalisata

  • Hyperphosphatasemia Tarda

  • VBCH

  • Sost-Related Sclerosing Bone Dysplasia

  • Endosteal Hyperostosis Autosomal Recessive

  • Sclerosteosis

  • Endosteal Hyperostosis, Autosomal Recessive

  • Hyperotosis Corticalis Generalisata Familiaris

  • Sost Sclerosing Bone Dysplasia

  • Smith-Lemli-Opitz Syndrome
Osteoporosis

  • Postmenopausal Osteoporosis

  • Osteoporosis, Postmenopausal

  • Bone Mineral Density Quantitative Trait Locus

  • Bmnd

  • Osteoporosis, Involutional

  • Osteoporosis, Susceptibility To

  • Osteoporosis, Postmenopausal, Susceptibility

  • Bone Mineral Density Variation Qtl, Osteoporosis

  • OSTEOP

  • Involutional Osteoporosis

  • Senile Osteoporosis

  • Osteoporosis Postmenopausal

  • Bone Mineral Density, Quantitative Trait Locus

  • Osteoporosis, Senile

  • Idiopathic Osteoporosis

  • Bone Rarefaction Nos

  • Type 1 Osteoporosis
Nanophthalmos

  • Nanophthalmia
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS05116 FRZB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS19333 Frzb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25824 Frzb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Felis catus FRZB VGNC VGNC:62372
Rattus norvegicus FRZB RGD RGD:1311315
Mus musculus FRZB MGD MGI:892032
Bos taurus FRZB VGNC VGNC:29124
Macaca mulatta FRZB VGNC VGNC:72819
Canis familiaris FRZB VGNC VGNC:53094
Others FRZB NCBI