Cyp1b1 - cytochrome P450, family 1, subfamily b, polypeptide 1 Gene

Species: Rattus norvegicus

Gene Type: protein coding
Gene ID: 25426

Summary

Enables monooxygenase activity. Involved in several processes, including positive regulation of macromolecule biosynthetic process; response to gonadotropin; and response to steroid hormone. Located in nucleus. Biomarker of breast adenocarcinoma and esophagus squamous cell carcinoma. Human ortholog(s) of this gene implicated in Peters anomaly; anterior segment dysgenesis 6; breast cancer; glaucoma (multiple); and lung squamous cell carcinoma. Orthologous to human CYP1B1 (Cytochrome P450 family 1 subfamily B member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp1b1 Products (1)

mRNA Protein Name
NM_012940.2 NP_037072.1 cytochrome P450 1B1

Gene Ontology

  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Références Source
enables monooxygenase activity IDA
IDA: Inferred from direct assay
15258110 RGD
enables oxidoreductase activity IDA
IDA: Inferred from direct assay
16893557 RGD
Biological Process GO Annotation Evidence Références Source
involved in DNA modification IMP
IMP: Inferred from mutant phenotype
24025706 RGD
involved in adrenal gland development IEP
IEP: Inferred from expression pattern
10098502 RGD
involved in benzene-containing compound metabolic process IDA
IDA: Inferred from direct assay
9806168 RGD
involved in benzene-containing compound metabolic process IMP
IMP: Inferred from mutant phenotype
24025706 RGD
involved in cellular response to cAMP IEP
IEP: Inferred from expression pattern
21389345 RGD
involved in cellular response to cortisol stimulus IEP
IEP: Inferred from expression pattern
8674863 RGD
involved in cellular response to luteinizing hormone stimulus IEP
IEP: Inferred from expression pattern
21389345 RGD
involved in cellular response to progesterone stimulus IEP
IEP: Inferred from expression pattern
8674863 RGD
involved in cellular response to toxic substance IMP
IMP: Inferred from mutant phenotype
31746392 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
10403529 RGD
involved in estrogen metabolic process IDA
IDA: Inferred from direct assay
23821647 RGD
involved in estrogen metabolic process IMP
IMP: Inferred from mutant phenotype
16893557 RGD
involved in estrous cycle IEP
IEP: Inferred from expression pattern
12223220 RGD
involved in ganglion development IEP
IEP: Inferred from expression pattern
17687037 RGD
involved in male gonad development IEP
IEP: Inferred from expression pattern
19074971 RGD
involved in positive regulation of DNA biosynthetic process IMP
IMP: Inferred from mutant phenotype
20439821 RGD
involved in positive regulation of apoptotic process IEP
IEP: Inferred from expression pattern
18336843 RGD
involved in positive regulation of reactive oxygen species metabolic process IMP
IMP: Inferred from mutant phenotype
20439821 RGD
involved in positive regulation of smooth muscle cell migration IMP
IMP: Inferred from mutant phenotype
20439821 RGD
involved in positive regulation of translation IMP
IMP: Inferred from mutant phenotype
20439821 RGD
involved in response to 3-methylcholanthrene IEP
IEP: Inferred from expression pattern
19889059 RGD
involved in response to arsenic-containing substance IEP
IEP: Inferred from expression pattern
23999541 RGD
involved in response to dexamethasone IEP
IEP: Inferred from expression pattern
9804617 RGD
involved in response to estradiol IEP
IEP: Inferred from expression pattern
19074971 RGD
involved in response to follicle-stimulating hormone IEP
IEP: Inferred from expression pattern
19074971 RGD
involved in response to indole-3-methanol IEP
IEP: Inferred from expression pattern
11719698 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
11739881 RGD
involved in response to organic cyclic compound IEP
IEP: Inferred from expression pattern
7744798 RGD
involved in response to steroid hormone IEP
IEP: Inferred from expression pattern
12704664 RGD
involved in response to toxic substance IEP
IEP: Inferred from expression pattern
7788849 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

cytochrome P450 1B1

  • CYPIB1

  • P450RAP

  • cytochrome P450, subfamily 1B, polypeptide 1

  • cytochrome P450RAP

  • hydroperoxy icosatetraenoate dehydratase

Related Agents

  • Approval
  • Pre-clinical Phase

Approval

Bioactive Molecules (2)
Cat. No. Nom du produit Effect
Pureté Rare Diseases
HY-B1234 Octinoxate 99.84% Unkown
HY-W017113 2-Mercaptobenzothiazole 99.85% Yes

Pre-clinical Phase

Bioactive Molecules (41)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-19340 TMS Inhibitor 99.40% Unkown
HY-133677 Mono(2-ethyl-5-hydroxyhexyl) phthalate 99.03% Unkown
HY-W007700 8-Bromooctanoic acid 99.89% Unkown
HY-101285 DMU2139 Inhibitor 98.0% Unkown
HY-152118 CYP1B1-IN-4 Inhibitor 99.09% Unkown
HY-124404 12(R)-HETE 99.90% Unkown
HY-N5132 (-)-Fenchone 98.0% Unkown
HY-159006 CYP1B1 ligand 3 Inhibitor 99.83% Unkown
HY-101284 DMU2105 Inhibitor 99.31% Unkown
HY-146393 PROTAC CYP1B1 degrader-1 Inhibitor 98.26% Unkown
HY-157942 CYP1B1-IN-7 Inhibitor 99.88% Unkown
HY-RS03443 CYP1B1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W713284 2-Ethylhexyl (E)-3-(4-(methoxy-d3)phenyl)acrylate 99.87% Unkown
HY-16676 7-Epi-docetaxel Activator 98.76% Unkown
HY-150557 CYP1B1-IN-1 Inhibitor / Unkown
HY-150558 CYP1B1-IN-2 Inhibitor / Unkown
HY-152079 CYP1B1-IN-3 Inhibitor / Unkown
HY-152196 CYP1B1-IN-5 Inhibitor 98.03% Unkown
HY-158429 PROTAC CYP1B1 degrader-2 / Unkown
HY-158430 CYP1B1 ligand 2 / Unkown
HY-161403 CYP1B1-IN-8 Inhibitor / Unkown
HY-162051 CYP1B1-IN-6 Inhibitor / Unkown
HY-174425 CYP1B1-IN-9 Inhibitor / Unkown
HY-175554 CYP1B1-IN-10 Inhibitor / Unkown
HY-175760 CYP1B1-IN-11 Inhibitor / Unkown
HY-175836 CYP1B1-IN-12 / Unkown
HY-178053 AHR agonist 10 / Unkown
HY-181550A CYP1B1-IN-14 TFA Inhibitor / Unkown
HY-181629 ZSTK3744 / Unkown
HY-181629A ZSTK3744 hydrochloride / Unkown
HY-183304 Anticancer agent 318 Substrate / Unkown
HY-187206 CYP1B1-IN-15 Inhibitor / Unkown
HY-101284A (E/Z)-DMU2105 Inhibitor / Unkown
HY-126308 (E/Z)-DMU2139 Inhibitor / Unkown
HY-158431 (S,R,S)-AHPC-Me-8-bromooctanoic acid / Unkown
HY-B1234S Octinoxate-13C,d3 / Unkown
HY-RS16945 Cyp1b1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS23388 Cyp1b1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-W472509 11-HETE Activator / Unkown
HY-W517092 1,2,3,4,7,8,9-Heptachlorodibenzofuran / Unkown
HY-W775354 1,2,3,4,7,8-Hexachlorodibenzofuran / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cyp1b1 NCBI NCBI:1545