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Cat. No.: HY-187206

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CYP1B1-IN-15

CYP1B1-IN-15 is a CYP1B1 inhibitor with an IC₅₀ of 1.47 nM, and it exhibits high selectivity against six major CYP subtypes. CYP1B1-IN-15 exerts competitive inhibitory effects by competing with substrates for binding to the active site of CYP1B1. CYP1B1-IN-15 enhances the inhibitory effect of Paclitaxel (HY-B0015) on the proliferation of paclitaxel-resistant cancer cells, and inhibits the migration and invasion of paclitaxel-resistant cancer cells. CYP1B1-IN-15 can be used in studies related to paclitaxel-resistant non-small cell lung cancer.

For research use only. We do not sell to patients.

Formula: C₁₈H₁₁F₂N₃O₂S
Molecular Weight:371.36

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

CYP1B1-IN-15 Chemical Structure

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
- Parmacokinetics
Chemical Information
Purity & Documentation
References
Calculators
Help & FAQs
Classifications
Bioz

Biological Activity

Description

IC₅₀ & Target^[1]

CYP1B1

1.47 nM (IC₅₀)

CYP1A1

0.41 μM (IC₅₀)

CYP1A2

> 100 μM (IC₅₀)

All Cytochrome P450 Isoforms :

In Vitro

CYP1B1-IN-15 (Compound C27) (10 μM; 48 h) exhibits low cytotoxicity toward normal BEAS-2B lung epithelial cells and A549 non-small cell lung cancer cells, and significantly inhibits the growth of paclitaxel-resistant A549/T cells at a concentration of 10 μM^[1].
CYP1B1-IN-15 (10 μM; 48 h) significantly enhances the sensitivity of paclitaxel-resistant A549/T cells to paclitaxel, reducing the IC₅₀ of paclitaxel by 4.8-fold at a concentration of 10 μM^[1].
CYP1B1-IN-15 (2.5-10 μM; 14 days) inhibits the clonogenic capacity of paclitaxel-resistant A549/T cells in a dose-dependent manner^[1].
CYP1B1-IN-15 (2.5-10 μM; 48 h) inhibits the migration of paclitaxel-resistant A549/T cells within 48 h in a dose-dependent manner^[1].
CYP1B1-IN-15 (2.5-10 μM; 24 h) effectively inhibits the invasion of paclitaxel-resistant A549/T cells^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:

A549/Taxol cell
Concentration:

10 μM
Incubation Time:

48 h
Result:

Reduced the paclitaxel IC₅₀ in A549/T cells from 10.59 μM to 2.20 μM, representing a 4.8-fold reversal of paclitaxel resistance.
Showed concentration-dependent resistance reversal with increasing CYP1B1-IN-15 doses.

Cell Proliferation Assay^[1]

Cell Line:

A549/Taxol cell
Concentration:

2.5, 5 and 10 μM
Incubation Time:

~14 days
Result:

Inhibited A549/T cell colony formation in a dose-dependent manner, with significant reduction in colony numbers observed at 5.0 μM.

Cell Invasion Assay^[1]

Cell Line:

A549/Taxol cell
Concentration:

2.5, 5 and 10 μM
Incubation Time:

24 h
Result:

Effectively blocked A549/T cell invasion at 5 μM, with an effect significantly superior to the positive control TMS.

Parmacokinetics

Species	Dose	Route	C_max	T_max	T_1/2	CL	V_dss	AUC_0-∞	Bioavailability
Mice^[1]	3 mg/kg	i.v.	4066.67 ng/mL	0.08 h	0.93 h	34.81 mL/min/kg	728.4 mL/kg	1436.33 ng·h/mL	/
Mice^[1]	30 mg/kg	p.o.	275.33 ng/mL	0.50 h	4.29 h	/	/	747.38 ng·h/mL	5.20 %

Chemical Information

Molecular Weight 371.36
Formula C₁₈H₁₁F₂N₃O₂S
SMILES

FC(F)OC(C=C1)=CC=C1NC(C2=CSC(C3=CC=C(C#N)C=C3)=N2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Wang T, et al. Discovery of highly selective and potent CYP1B1 inhibitors for overcoming paclitaxel resistance in A549/Taxol cells. European journal of medicinal chemistry. 2026 Jun 30;317:119116. [Content Brief]

Calculators

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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100 mg

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Biological Activity
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Purity & Documentation
References

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CYP1B1-IN-15

All Cytochrome P450 Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

CYP1B1-IN-15 Related Classifications

HY-187206 Related Classifications