CYP1B1-IN-12
CYP1B1-IN-12 is a selective cytochrome P450 1B1 (CYP1B1) inhibitor with an IC50 of 6.05 nM. CYP1B1-IN-12 demonstrates remarkable selectivity, exceeding 1600-fold and 16,000-fold over CYP1A1 and CYP1A2, respectively. CYP1B1-IN-12 can enhance Paclitaxel (HY-B0015)-mediated apoptosis and restore Paclitaxel sensitivity in A549/Taxol-resistant cells. CYP1B1-IN-12 can inhibit the epithelial-mesenchymal transition process and reduce cells migration and invasion. CYP1B1-IN-12 can be used for the research of cancer, such as non-small cell lung cancer (NSCLC).
For research use only. We do not sell to patients.
- Formula: C17H10IN3OS
- Molecular Weight:431.25
-
Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
-
Biological Activity
-
Chemical Information
- Purity & Documentation
- References
-
Help & FAQs
Biological Activity
|
CYP1B1 6.05 nM (IC50) |
CYP1B1-IN-12 (Compound B14) (10 μM) shows less than 50% inhibition against 7 major CYP enzymes including CYP2B6 and CYP2C8, indicating low potential for drug-drug interactions[1].
Compound B14 (0-20 μM, 48 h) shows IC50 values >20 μM in HUVEC and BEAS-2B cells[1].
CYP1B1-IN-12 (2-8 μM, 48 h) dose-dependently inhibits proliferation companied with Paclitaxel (HY-B0015) in A549/Tax cells[1].
CYP1B1-IN-12 (2-8 μM, 14 days) reduces colony numbers companied with Paclitaxel in A549/Tax cells[1].
CYP1B1-IN-12 (8 μM, 48 h) increases the proportion of total apoptotic A549/Tax cells companied with Paclitaxel[1].
CYP1B1-IN-12 (1-4 μM, 24 h) inhibits migration and invasion in A549/Tax cells[1].
CYP1B1-IN-12 (1-4 μM, 48 h) upregulates E-cadherin levels and downregulates N-cadherin and vimentin levels in A549/Tax cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
-
Cell Line:A549/Tax cells
-
Concentration:1, 2 and 4 μM
-
Incubation Time:48 h
-
Result:Upregulated E-cadherin levels.
Downregulated N-cadherin and vimentin levels.
Chemical Information
-
Molecular Weight 431.25
-
Formula C17H10IN3OS
-
SMILES
IC1=CC=C(C=C1)C2=NOC(C3=NC(C4=CC=CC=C4)=CS3)=N2
-
Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Powered by Bioz