2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP1B1-IN-8

CYP1B1-IN-8 (Compound 14b) is a CYP1B1 inhibitor (IC50: 4.14 × 10–5 nM). CYP1B1-IN-8 reduces the resistance in A549 cells to Paclitaxel (HY-B0015), and inhibits cell migration and invasion.

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CYP1B1-IN-8

CYP1B1-IN-8 Chemical Structure

CAS No. : 3052218-49-9

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CYP1B1-IN-8 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A CYP3A4 CYP17A1

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Description

CYP1B1-IN-8 (Compound 14b) is a CYP1B1 inhibitor (IC50: 4.14 × 10–5 nM). CYP1B1-IN-8 reduces the resistance in A549 cells to Paclitaxel (HY-B0015), and inhibits cell migration and invasion[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
11.13 nM
Compound: 14b
Reversal of DMBA-stimulated PTX resistance in human A549 cells assessed as PTX IC50 for inhibition of cell viability at 10 uM incubated for 36 hrs in presence of DMBA and PTX by MTT assay (Rvb = 119 +/-2.62 nM)
Reversal of DMBA-stimulated PTX resistance in human A549 cells assessed as PTX IC50 for inhibition of cell viability at 10 uM incubated for 36 hrs in presence of DMBA and PTX by MTT assay (Rvb = 119 +/-2.62 nM)
[PMID: 38509663]
Molecular Weight

411.67

Formula

C16H15ClIN3
CAS No.
SMILES

IC1=CC=C(C2=NC3=CC=CC=C3C(NCC)=N2)C=C1.Cl
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Purity & Documentation
References
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CYP1B1-IN-8 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP1B1-IN-83052218-49-9Cytochrome P450CYPsmigrationinvasionA549Inhibitorinhibitorinhibit

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