CYP1B1-IN-3
CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways.
For research use only. We do not sell to patients.
- CAS No.: 2872575-51-2
- Formula: C20H16FN3O2S2
- Molecular Weight:413.49
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
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CYP1B1 6.6 nM (IC50) |
CYP1A1 347.3 nM (IC50) |
CYP1A2 >10000 nM (IC50) |
CYP1B1-IN-3 (compound 77) (3.75-30.0 μM; 72 h) increases the sensitivity of A549/Taxol cells to Taxol (0.06-1 μM)[1].
CYP1B1-IN-3 (2.5, 5, 10 µM) inhibits the cell migration and invasion in DMBA-induced A549 cells that overexpressed CYP1B1 and A549/Taxol cells that overexpressed CYP1B1[1].
CYP1B1-IN-3 (2.5, 5, 10 µM; 24 h) inhibits AKT/ERK, FAK/SRC, and EMT pathways in A549/Taxol cells[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:A549/Taxol cells
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Concentration:2.5, 5, 10 µM
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Incubation Time:24 h
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Result:Decreased the expression of P-gp, p-AKT, AKT, p-ERK1/2 (T202/Y204), ERK1/2, p-FAK (Y576), FAK, p-SRC in a dose-dependent manner.
Chemical Information
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CAS No. 2872575-51-2
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Molecular Weight 413.49
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Formula C20H16FN3O2S2
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SMILES
COC1=CC(NC2=NC(C3=NC(C4=C(C=CC=C4)F)=CS3)=CS2)=CC(OC)=C1
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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