2. Metabolic Enzyme/Protease
  3. Cytochrome P450
  4. CYP1B1-IN-3

CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways.

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CYP1B1-IN-3 Chemical Structure

CYP1B1-IN-3 Chemical Structure

CAS No. : 2872575-51-2

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CYP1B1-IN-3 Related Antibodies

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP2D6 CYP3A4 CYP17A1

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Description

CYP1B1-IN-3 is a potent and selective CYP1B1 inhibitor with IC50 values of 6.6, 347.3, >10000 nM for CYP1B1, CYP1A1, CYP1A2, respectively. CYP1B1-IN-3 inhibits cell migration and invasion. CYP1B1-IN-3 inhibits P-gp, AKT/ERK, FAK/SRC, and EMT pathways[1].

IC50 & Target[1]

CYP1B1

6.6 nM (IC50)

CYP1A1

347.3 nM (IC50)

CYP1A2

>10000 nM (IC50)

In Vitro

CYP1B1-IN-3 (compound 77) (3.75-30.0 μM; 72 h) increases the sensitivity of A549/Taxol cells to Taxol (0.06-1 μM)[1].
CYP1B1-IN-3 (2.5, 5, 10 µM) inhibits the cell migration and invasion in DMBA-induced A549 cells that overexpressed CYP1B1 and A549/Taxol cells that overexpressed CYP1B1[1].
CYP1B1-IN-3 (2.5, 5, 10 µM; 24 h) inhibits AKT/ERK, FAK/SRC, and EMT pathways in A549/Taxol cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CYP1B1-IN-3 Related Antibodies

Western Blot Analysis[1]

Cell Line: A549/Taxol cells
Concentration: 2.5, 5, 10 µM
Incubation Time: 24 h
Result: Decreased the expression of P-gp, p-AKT, AKT, p-ERK1/2 (T202/Y204), ERK1/2, p-FAK (Y576), FAK, p-SRC in a dose-dependent manner.
Molecular Weight

413.49

Formula

C20H16FN3O2S2
CAS No.
SMILES

COC1=CC(NC2=NC(C3=NC(C4=C(C=CC=C4)F)=CS3)=CS2)=CC(OC)=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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CYP1B1-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CYP1B1-IN-32872575-51-2Cytochrome P450CYPsInhibitorinhibitorinhibit

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