WNT2B - Wnt family member 2B Gene

Also Known as WNT13

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 7482

About WNT2B

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:112,466,541-112,530,165 (from NCBI)

This gene has 4 transcripts (splice variants), 200 orthologues, 18 paralogues and is associated with 1 phenotype. Broad expression in ovary (RPKM 4.3), skin (RPKM 3.1) and 21 other tissues.

Summary

This gene encodes a member of the wingless-type MMTV integration site (Wnt) family of highly conserved, secreted signaling factors. Wnt family members function in a variety of developmental processes including regulation of cell growth and differentiation and are characterized by a WNT-core domain. This gene may play a role in human development as well as carcinogenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]

WNT2B Products (3)

mRNA Protein Name
NM_001291880.1 NP_001278809.1 protein Wnt-2b isoform 3
NM_004185.4 NP_004176.2 protein Wnt-2b isoform WNT-2B1
NM_024494.3 NP_078613.1 protein Wnt-2b isoform WNT-2B2

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Références Source
involved in canonical Wnt signaling pathway IDA
IDA: Inferred from direct assay
11741304 GOA
involved in canonical Wnt signaling pathway IMP
IMP: Inferred from mutant phenotype
15135146 GOA
involved in chondrocyte differentiation IEP
IEP: Inferred from expression pattern
15135146 GOA
involved in forebrain regionalization IEP
IEP: Inferred from expression pattern
15164427 GOA
involved in hematopoietic stem cell proliferation IDA
IDA: Inferred from direct assay
9787155 GOA
involved in male gonad development IEP
IEP: Inferred from expression pattern
17848411 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

WNT2B Protein Structure

wnt

wnt: wnt family (71 - 380)

  • 0
  • 100
  • 200
  • 300
  • 391 a.a.
Protein Preferred Names Protein Names

protein Wnt-2b

  • XWNT2, Xenopus, homolog of

WNT2B Anticorps

Cat. No. Nom du produit Application Reactivity
HY-P82679 Wnt2b Antibody (YA2424) WB, ICC/IF Human, Mouse, Rat
HY-P82679A Wnt2b Antibody (YA2424)(PBS only) WB, ICC/IF Human, Mouse, Rat

Related Diseases

Diseases Alias
Diarrhea 9

  • DIAR9

  • Diarrhea, Type 9
Diarrhea

  • Diarrhoea

  • Diarrhea Of Presumed Infectious Origin
Osmotic Diarrhea
Gastric Cancer

  • Stomach Cancer

  • Gastric Carcinoma

  • Stomach Carcinoma

  • Gastric Cancer, Somatic

  • Gastric Neoplasm

  • Carcinoma Of Stomach

  • Stomach Neoplasms

  • Malignant Neoplasm Of Stomach

  • Gastric Cancer Risk After H. Pylori Infection

  • Cancer Of The Stomach

  • Adult Stomach Cancer

  • Adult Stomach Carcinoma

  • GASC

  • Gastric Cancer Intestinal

  • Gastric Cancers

  • Gastric Carcinomas

  • Cancer, Gastric

  • Stomach Neoplasm

  • Malignant Neoplasm Of Body Of Stomach

  • Malignant Tumor Of Lesser Curve Of Stomach

  • Gastrocarcinoma Of Unspecified Site

  • Leather Bottle Stomach

  • Carcinoma Of Fundus Of Stomach

  • Cancer Of Fundus Of Stomach

  • Primary Malignant Neoplasm Of Body Of Stomach

  • Cancer Of Body Of Stomach

  • Primary Malignant Neoplasm Of Pyloric Antrum

  • Pyloric Antrum Cancer

  • Malignant Tumour Of Stomach
Neural Tube Defects

  • Spina Bifida

  • Neural Tube Defect

  • NTD

  • Neural Tube Defects, Susceptibility To

  • Spinal Dysraphism

  • Spina Bifida, Susceptibility To

  • Rachischisis

  • Cleft Spine

  • Open Spine

  • Hydrocele Spinalis

  • Neural Tube Defect Nos

  • Sb - [Spina Bifida]

  • Spinal Hernia Nos

  • Spinal Fissure Nos
Colorectal Cancer

  • Colon Cancer

  • Colorectal Carcinoma

  • Colon Carcinoma

  • Colorectal Cancer, Susceptibility To

  • Carcinoma Of Colon

  • CRC

  • Colorectal Cancer With Chromosomal Instability, Somatic

  • Colon Cancer, Somatic

  • Colon Cancer, Susceptibility To

  • Colonic Neoplasms

  • Colorectal Neoplasms

  • Colorectal Cancer, Somatic

  • Colon Cancer, Advanced, Somatic

  • Colonic Carcinoma

  • Colorectal Carcinomas

  • Colon Cancers

  • Colorectal Cancers

  • Cancer, Colorectal, Somatic

  • Cancer, Colon

  • Cancer, Colorectal, Susceptibility To

  • Colorectal Neoplasm

  • Colonic Neoplasm

  • Malignant Tumor Of Colon
Exudative Vitreoretinopathy

  • Familial Exudative Vitreoretinopathy

  • Fevr

  • Criswick-Schepens Syndrome

  • Exudative Vitreoretinopathy, Familial

  • Vitreoretinopathy, Exudative )

  • Exudative Vitreoretinopathy 1
Norrie Disease

  • Atrophia Bulborum Hereditaria

  • Episkopi Blindness

  • Pseudoglioma

  • ND

  • Norrie-Warburg Disease

  • Anderson-Warburg Syndrome

  • Fetal Iritis Syndrome

  • Norrie Syndrome

  • Norrie-Warburg Syndrome

  • Ndp

  • Congenital Progressive Oculo-Acoustico-Cerebral Degeneration

  • Norrie'S Disease

  • Oligophrenia Microphthalmus

  • Pseudoglioma Congenita

  • Whitnall-Norman Syndrome
Robinow Syndrome

  • Acral Dysostosis With Facial And Genital Abnormalities

  • Fetal Face Syndrome

  • Robinow Dwarfism

  • Mesomelic Dwarfism-Small Genitalia Syndrome

  • Robinow-Silverman-Smith Syndrome

  • Costovertebral Segmentation Defect With Mesomelia

  • Covesdem Syndrome

  • Robinow'S Syndrome

  • Robinow-Silverman Syndrome
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Cat. No. Nom du produit
Effect
Pureté
Rare Diseases
HY-RS15833 WNT2B Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS22922 Wnt2b Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS29436 Wnt2b Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Bos taurus WNT2B VGNC VGNC:36958
Macaca mulatta WNT2B VGNC VGNC:78797
Rattus norvegicus WNT2B RGD RGD:69346
Felis catus WNT2B VGNC VGNC:80403
Mus musculus WNT2B MGD MGI:1261834
Canis familiaris WNT2B VGNC VGNC:48423
Others WNT2B NCBI