HDAC8-IN-6
HDAC8-IN-6 (compound 3) is a potent HDAC8 inhibitor with an IC50 of 5.1 μM. HDAC8-IN-6 shows cytotoxicity.
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- CAS No.: 3036403-81-0
- Formule: C19H18IN3O2
- Masse moléculaire:447.27
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Help & FAQs
Activité biologique
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HDAC8 5.1 μM (IC50) |
HDAC4 23.1 μM (IC50) |
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Cell Line
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Type | Value | Description | References |
|---|---|---|---|---|
| HEL | IC50 |
>200 μM
Compound: 3
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Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against HEL cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
| HL-60 | IC50 |
161 μM
Compound: 3
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Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human HL-60 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
| MOLM-13 | IC50 |
7.08 μM
Compound: 3
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Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human MOLM-13 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
| MV4-11 | IC50 |
8.23 μM
Compound: 3
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Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human MV4-11 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
| OCI-AML-3 | IC50 |
27.17 μM
Compound: 3
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Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human OCI-AML-3 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
| SET-2 | IC50 |
>200 μM
Compound: 3
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Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human SET2 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
| THP-1 | IC50 |
46.5 μM
Compound: 3
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Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
Cytotoxicity against human THP-1 cells assessed as reduction in cell viability incubated for 72 hrs by CellTiter-Blue cell viability assay
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[PMID: 38113354] |
Chemical Information
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CAS No. 3036403-81-0
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Masse moléculaire 447.27
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Formule C19H18IN3O2
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SMILES
C[N+]1=CC=C(NC(CC(N2CC3=C(C=CC=C3)C2)=O)=O)C(C#C)=C1.[I-]
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
HDAC8-IN-6 Related Classifications
HY-163143 Related Classifications
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