Koshidacin B
Koshidacin B is an antiplasmodial cyclic tetrapeptide with antiplasmodial activity against P. falciparum FCR3 and K1 strain with IC50 values of 0.89 and 0.83 μM, respectively. Koshidacin B suppresses malaria parasites in vivo, it can be used for the research of parasites infection.
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- CAS No.: 2925302-01-6
- Formule: C28H40N4O7
- Masse moléculaire:544.64
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
- Pureté et documentation
- Références
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Activité biologique
IC50: 0.89 μM (P. falciparum FCR3 strain), 0.83 μM (P. falciparum K1 strain), 14.7 μM (human MRC-5 cells)[1]
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Cell Line
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Type | Value | Description | References |
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| MRC5 | CC50 |
14.7 μM
Compound: 2
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Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
Cytotoxicity against human MRC5 cells assessed as reduction in cell viability after 24 hrs by MTT assay
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[PMID: 36282784] |
Koshidacin B (72 h) shows antiplasmodial activity against chloroquine-sensitive P. falciparum FCR3 strain and chloroquine-resistant P. falciparum K1 strain with IC50 values of 0.89 and 0.83 μM, respectively[1]. Koshidacin B (7 d) shows cytotoxicity against human MRC-5 cells with an IC50 value of 14.7 μM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:P. berghei N strain-infected ICR (CD1) mice[1]
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Dosage:30 mg/kg
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Administration:Intraperitoneal injection; 30 mg/kg; once daily; for 4 days
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Result:Suppressed 41% of malaria parasites.
Chemical Information
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CAS No. 2925302-01-6
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Masse moléculaire 544.64
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Formule C28H40N4O7
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SMILES
OC[C@H](O)C(CCCCC[C@H](NC([C@H]1CCCN1C([C@@H](NC(C(C)(C)N2)=O)CC3=CC=CC=C3)=O)=O)C2=O)=O
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Structure Classification
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Initial Source
Pochonia boninensis
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Koshidacin B Related Classifications
HY-N10624 Related Classifications
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