Meclonazepam
Based on 1 Customer Validation
Meclonazepam (Ro 11-3128) is a benzodiazepine compound with anxiolytic effect. Meclonazepam is active against immature S. mansoni. Meclonazepam (30 μM) eliminates 100% of immature parasites. Meclonazepam has a anti-schistosomal effect.
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- Pureté: 99.97%
- CAS No.: 58662-84-3
- Formule: C16H12ClN3O3
- Masse moléculaire:329.74
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Stockage:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
To place orders, for customer services and technical support, please contact: MedChemExpress USA
Tel: 609-228-6898 E-mail: [email protected] [email protected]
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Activité biologique
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Chemical Information
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Solvant et solubilité
- Pureté et documentation
- Références
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Help & FAQs
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Activité biologique
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Schistosome |
Meclonazepam causes initially a massive spastic paralysis of immature S. mansoni[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Meclonazepam (40 and 80 mg/kg) Has highly significant effect on the immature schistosomes[2].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:Adult experimentally naive male Mongolian gerbils (Meriones unguiculatus)[1]
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Dosage:0.1, 0.3, 1.0, 3.0, 5.6 mg/kg
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Administration:Administration intraperitoneally (IP) 5 min prior to training onset.
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Result:The ED50 of 0.77-0.78 mg/kg at the 5 min post-injection (p.i.).
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Animal Model:CB6F1 mice were infected with single-sex male S. mansoni cercariae 28 days before treatment[2]
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Dosage:40 and 80 mg/kg
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Administration:Administered by gavage either as single drugs or in a sequence consisting of 1 dose of Praziquantel (PZQ), a 5-min interval, 1 dose of Ro, a 15-min interval, a second dose of PZQ.
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Result:PZQ had no significant effect on the immature schistosomes, whereas Ro 11-3128 was highly effective.
Chemical Information
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CAS No. 58662-84-3
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Appearance Solid
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Masse moléculaire 329.74
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Formule C16H12ClN3O3
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Color White to off-white
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SMILES
O=C1NC2=CC=C([N+]([O-])=O)C=C2C(C3=CC=CC=C3Cl)=N[C@H]1C
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Synonyms
Ro 11-3128; Ro 11-3128/002
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Solvant et solubilité
DMSO : 50 mg/mL (151.63 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: 2.5 mg/mL (7.58 mM); Clear solution; Need ultrasonic
This protocol yields a clear solution of 2.5 mg/mL.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Pureté et documentation
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Fiche technique (280 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Instruction de manipulation (2659 KB)
Références
[1]. T U Järbe, et al. Cueing effects of anxiolytic benzodiazepines (DZP and Ro 11-3128): stereospecificity and antagonism by the convulsant benzodiazepine Ro 5-3663. Psychopharmacology (Berl). 1988;94(4):501-6. [Content Brief]
[2]. L Pica-Mattoccia, et al. Praziquantel and the benzodiazepine Ro 11-3128 do not compete for the same binding sites in schistosomes. Parasitology. 2008 Jan;135(Pt 1):47-54. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
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| DMSO | 1 mM | 3.0327 mL | 15.1635 mL | 30.3269 mL | 75.8173 mL |
| 5 mM | 0.6065 mL | 3.0327 mL | 6.0654 mL | 15.1635 mL | |
| 10 mM | 0.3033 mL | 1.5163 mL | 3.0327 mL | 7.5817 mL | |
| 15 mM | 0.2022 mL | 1.0109 mL | 2.0218 mL | 5.0545 mL | |
| 20 mM | 0.1516 mL | 0.7582 mL | 1.5163 mL | 3.7909 mL | |
| 25 mM | 0.1213 mL | 0.6065 mL | 1.2131 mL | 3.0327 mL | |
| 30 mM | 0.1011 mL | 0.5054 mL | 1.0109 mL | 2.5272 mL | |
| 40 mM | 0.0758 mL | 0.3791 mL | 0.7582 mL | 1.8954 mL | |
| 50 mM | 0.0607 mL | 0.3033 mL | 0.6065 mL | 1.5163 mL | |
| 60 mM | 0.0505 mL | 0.2527 mL | 0.5054 mL | 1.2636 mL | |
| 80 mM | 0.0379 mL | 0.1895 mL | 0.3791 mL | 0.9477 mL | |
| 100 mM | 0.0303 mL | 0.1516 mL | 0.3033 mL | 0.7582 mL |
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