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Cat. No.: HY-183837

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PROTAC STAT6 degrader-8

PROTAC STAT6 degrader-8 is a STAT6 PROTAC degrader with a DC₅₀ value >0.1 μM and a DC_max value > 0.01 μM. PROTAC STAT6 degrader-8 has the potential for application in inflammation-related diseases.

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CAS No.: 3077464-49-1
Formule: C₄₁H₄₄FN₉O₆
Masse moléculaire:777.84

Stockage:

Please store the product under the recommended conditions in the Certificate of Analysis.

PROTAC STAT6 degrader-8 Chemical Structure

CAS No.: 3077464-49-1

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références
Calculators
Help & FAQs
Classifications
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Activité biologique

Description

IC₅₀ & Target^[1]

STAT6

Voir tous les produits spécifiques à Isoform PROTACs :

Voir tous les produits spécifiques à Isoform STAT :

In Vitro

PROTAC STAT6 degrader-8 (I-22) is a STAT6 PROTAC degrader that recruits STAT6 protein to E3 ubiquitin ligase and degrades it^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 3077464-49-1
Masse moléculaire 777.84
Formule C₄₁H₄₄FN₉O₆
SMILES

O=C(N(C)C)C1=CC2=C(C(C#CCCC(N3CCN(CC3)C4=CC=C(NC5C(NC(CC5)=O)=O)C=C4F)=O)=CC(C6=CCCN(C6)C(CCN7N=NC=C7)=O)=C2)O1
Livraison

Room temperature in continental US; may vary elsewhere.
Stockage

Please store the product under the recommended conditions in the Certificate of Analysis.

Pureté et documentation

Instruction de manipulation (2659 KB)

Références

[1]. Bin Yang, et al. Stat6 degraders and uses thereof. WO2025049820A1. 2026-02-28.

Calculators

Calculateur de molarité

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Calculateur de dilution

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

Concentration _(start) Concentration _(start)

Volume _(start) Volume _(start)

Concentration _(final) Concentration _(final)

Volume _(final) Volume _(final)

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Activité biologique
- Description
- IC₅₀ & Target
- In Vitro
Chemical Information
Pureté et documentation
Références

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PROTAC STAT6 degrader-8

Voir tous les produits spécifiques à Isoform PROTACs

Voir tous les produits spécifiques à Isoform STAT

Activité biologique

Chemical Information

Pureté et documentation

Références

Calculators

Help & FAQs

PROTAC STAT6 degrader-8 Related Classifications

HY-183837 Related Classifications