R-MDMA
R-MDMA, 4-methylenedioxymethamphetamine (MDMA) isomer, is a 5-HT2A/5-HT2C receptor antagonist with an IC50 of 629 and 61.4 nM. R-MDMA promotes cortical neuron growth. R-MDMA facilitates fear extinction learning and produces antidepressant-like effects in preclinical rodent models. R-MDMA can be used for the researches of post-traumatic stress disorder and depression.
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- Formule: C12H16O2
- Masse moléculaire:192.25
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Stockage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Activité biologique
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5-HT2C Receptor 61.4 nM (IC50) |
5-HT2A Receptor 629 nM (IC50) |
R-MDMA (10 pM-10 μM; 24-72 h) promotes cortical neuron growth[1].
R-MDMA (100 μM; 15 min) induces serotonin efflux from SERT-expressing HEK293T cells[1].
R-MDMA (10 pM-100 μM; 5 min) acts as a moderately potent antagonist at 5-HT2A receptors in HEK293T cells with an IC50 of 629 nM[1].
R-MDMA (10 pM-100 μM; 5 min) acts as a moderately potent antagonist at 5-HT2C receptors in HEK293T cells with an IC50 of 61.4 nM[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Cell Line:cortical neurons
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Concentration:10 pM, 1, 100 nM, 10 μM
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Incubation Time:24, 72 h
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Result:Promoted cortical neuron growth.
R-MDMA (12.5-25 mg/kg; i.p.; single dose; 30 min prior to extinction training) facilitates fear extinction learning, producing sustained reductions in freezing behavior in a mouse fear conditioning model[1].
R-MDMA (12.5-25 mg/kg; i.p.; single dose) at 25 mg/kg produces a sustained antidepressant-like effect in the mouse tail suspension test[1].
R-MDMA (20 mg/kg; i.p.; single dose; administered during social interaction training sessions) does not produce a statistically significant social conditioned place preference in mice[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
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Animal Model:C57BL/6J (9-13 weeks old, mixed male and female)[1]
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Dosage:12.5 mg/kg; 25 mg/kg; 50 mg/kg
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Administration:i.p.; single dose
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Result:Decreased locomotion at 12.5 mg/kg.
Increased locomotion at 50 mg/kg.
Caused significantly less time spent in the arena center (increased thigmotaxis) at all doses.
Did not induce head-twitch response at any dose.
Caused transient decrease in body temperature at 30 min post-administration of 25 mg/kg and 50 mg/kg, which resolved by 60 min.
Produced no body temperature changes at 12.5 mg/kg.
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Animal Model:Depressant C57BL/6J (9-13 weeks old, mixed male and female)[1]
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Dosage:12.5 mg/kg; 25 mg/kg
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Administration:i.p.; single dose
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Result:Reduced immobility time to a comparable extent to positive control Ketamine (3 mg/kg) at 25 mg/kg.
Did not produce statistically significant antidepressant-like response at 12.5 mg/kg.
Had its antidepressant-like effect blocked when pretreated with 5-HT2 antagonist Ketanserin (HY-10562) (4 mg/kg, i.p., 10 min prior) at 25 mg/kg.
Chemical Information
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Masse moléculaire 192.25
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Formule C12H16O2
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SMILES
C[C@@H](CC1=CC2=C(C=C1)OCO2)CC
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Livraison
Room temperature in continental US; may vary elsewhere.
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Stockage
Please store the product under the recommended conditions in the Certificate of Analysis.
Pureté et documentation
Références
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
R-MDMA Related Classifications
HY-186170 Related Classifications
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