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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
5 Results for "
PTPN2/1
" in MedChemExpress (MCE) Product Catalog:
Products (5)
5 Results for "PTPN2/1" in MCE Product Catalog:
Synonyms: PTPN2/1-IN-1
Target:
Domaines de recherche:
Tegeprotafib (PTPN2/1-IN-1) (Compound 124) is an orally active PTPN1 and PTPN2 inhibitor with IC50s of 4.4 nM and 1-10 nM against PTPN2 and PTP1B, respectively .
Cat. No.: HY-162428
CAS No.: 3032920-59-2
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Domaines de recherche:
PTPN2/1-IN-3 (compound 4) is a modified, orally active PTPN2/N1 inhibitor based on ABBV-CLS-484 (HY-145923). PTPN2/1-IN-3 has anti-tumor effects, inhibiting PTPN2 with an IC50 of 9.3 nM and having an oral bioavailability of 93% in mice .
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PTPN2/1-IN-2 is a PTPN2/1 antagonist that can be used in various tumor research .
Cat. No.: HY-178716
CAS No.: 3093350-55-8
Target:
Domaines de recherche:
PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8+ T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models .
Cat. No.: HY-W585105
CAS No.: 2652033-78-6
Domaines de recherche:
PTPN2 ligand 3 is the target protein ligand of PROTAC PTPN2 degrader-1 (HY-148691). PROTAC PTPN2 degrader-1 is a PROTAC degrader that targets non-receptor protein tyrosine phosphatase 2 (PTPN2) .
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Protocols
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