107200-92-0
Chemical Structure
Cathepsin G
- CAS No.: 107200-92-0
- Formula:C1163H1883N383O327S11
- Molecular Weight:26815.87
SMILES: [Cathepsin G]
Biological Activity: Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases[1][2][3][4][5][6].
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Cathepsin G | Cathepsin G is a pH-dependent serine protease. Cathepsin G hydrolyzes diverse synthetic and protein substrates and remodels extracellular matrix. Cathepsin G exerts immunomodulatory effects via recruiting phagocytes, enhancing T cell motility, activating ERK1/2 and p38 MAPK signaling, and mediating PKCζ membrane translocation. Cathepsin G regulates inflammatory responses by cleaving inflammatory mediators. Cathepsin G participates in vascular regulation by converting angiotensin I to angiotensin II. Cathepsin G induces PAR4-dependent platelet activation, facilitates platelet-neutrophil aggregation, and mediates VITT-related NETosis, thrombus formation. Cathepsin G can be used for the research of immune thrombotic thrombocytopenia, cardiovascular disease, and select autoimmune and inflammatory diseases. | |||||||||||||||||||||
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References
- [1]. Starkey PM. Human cathepsin G: catalytic and immunological properties. Biochemical Journal, 1976, 155(2): 273-278.
- [2]. Tonnesen MG, et al. Identification of a human neutrophil angiotension II-generating protease as cathepsin G. J Clin Invest. 1982;69(1):25-30. [Content Brief]
- [3]. Carnevale R, et al. PAD4-Induced NETosis Via Cathepsin G-Mediated Platelet-Neutrophil Interaction in ChAdOx1 Vaccine-Induced Thrombosis-Brief Report. Arterioscler Thromb Vasc Biol. 2023;43(10):e396-e403. [Content Brief]
- [4]. Migeotte I, et al. Formyl peptide receptors: a promiscuous subfamily of G protein-coupled receptors controlling immune responses. Cytokine Growth Factor Rev. 2006;17(6):501-519. [Content Brief]
- [5]. LaRosa CA, et al. Human neutrophil cathepsin G is a potent platelet activator. J Vasc Surg. 1994;19(2):306-319. [Content Brief]
- [6]. Gao S, et al. Cathepsin G and Its Role in Inflammation and Autoimmune Diseases. Arch Rheumatol. 2018;33(4):498-504. Published 2018 Jan 22. [Content Brief]
