Cathepsin G and Its Role in Inflammation and Autoimmune Diseases

  • Arch Rheumatol. 2018 Jan 22;33(4):498-504. doi: 10.5606/ArchRheumatol.2018.6595.
Siming Gao  1 ,  Honglin Zhu  1 ,  Xiaoxia Zuo  1 ,  Hui Luo  1
Affiliations
  • 1. Department of Rheumatology, Xiangya Hospital, Hunan, China.
PMID: 30874236 DOI: 10.5606/ArchRheumatol.2018.6595
Abstract

Cathepsin G belongs to the neutrophil serine proteases family, known for its function in killing pathogens. Studies over the past several years indicate that Cathepsin G has important effects on inflammation and immune reaction, and may be a key factor in the pathogenesis of some autoimmune diseases. In this article, we discuss the roles of Cathepsin G in inflammation, immune reaction, and autoimmune diseases. To our knowledge, this is the first study providing important information about Cathepsin G in the pathogenesis of autoimmune diseases and suggesting that Cathepsin G may be a new biomarker or treatment target.

Keywords
Autoimmune disease; cathepsin G; immune reaction; inflammation.
Products