14101-61-2
14101-61-2
Chemical Structure
γ-Tocotrienol
- CAS No.: 14101-61-2
- Formula:C28H42O2
- Molecular Weight:410.63
IUPAC Name: (R)-2,7,8-trimethyl-2-((3E,7E)-4,8,12-trimethyltrideca-3,7,11-trien-1-yl)chroman-6-ol
InChIKey: OTXNTMVVOOBZCV-WAZJVIJMSA-N
SMILES: OC1=C(C)C(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1
Biological Activity: γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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γ-Tocotrienol | 99.67% | γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment. | ||||||||||||||||||||
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γ-Tocotrienol (Standard) | ≥98% | γ-Tocotrienol (Standard) is the analytical standard of γ-Tocotrienol. This product is intended for research and analytical applications. γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a novel radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment. | ||||||||||||||||||||
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References
- [1]. M A Newaz, et al. Nitric Oxide Synthase Activity in Blood Vessels of Spontaneously Hypertensive Rats: Antioxidant Protection by Gamma-Tocotrienol. J Physiol Pharmacol. 2003 Sep;54(3):319-27. [Content Brief]
- [2]. Ding Y, et al. γ-Tocotrienol reverses multidrug resistance of breast cancer cells through the regulation of the γ-Tocotrienol-NF-κB-P-gp axis. J Steroid Biochem Mol Biol. 2021 May;209:105835. [Content Brief]
- [3]. Lee SG, et al. γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs. J Nucl Med. 2021 Apr;62(4):584-590. [Content Brief]
