Cat. No.: HY-108694

γ-Tocotrienol

4 Cited Publications

Customer Review

Based on 4 publication(s) in Google Scholar

γ-Tocotrienol is an active form of vitamin E. γ-tocotrienol reverses the multidrug resistance (MDR) of breast cancer cells through the signaling pathway of NF-κB and P-gp. γ-Tocotrienol is also a radioprotector agent, can mitigate bone marrow radiation damage during targeted radionuclide treatment.

For research use only. We do not sell to patients.

Purity: 99.67%
CAS No.: 14101-61-2
Formula: C₂₈H₄₂O₂
Molecular Weight:410.63

Storage:

Pure form -20°C, 3 years ; In solvent -80°C, 6 months , -20°C, 1 month

γ-Tocotrienol Chemical Structure

CAS No.: 14101-61-2

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biological Activity
- Description
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Publications (4)
Solvent & Solubility
- In Vitro
- In Vivo
Purity & Documentation
References
Help & FAQs
Bioz

Biological Activity

Description

All Endogenous Metabolite Isoforms :

All NF-κB Isoforms :

Cellular Effect

Cell Line	Type	Value	Description	References
MCF-10A	IC₅₀	4.4 μM Compound: 1	Antiproliferative activity against human MCF10A cells by MTT assay Antiproliferative activity against human MCF10A cells by MTT assay	[PMID: 23274571]
MCF7	IC₅₀	11.4 μM Compound: 2	Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay Antiproliferative activity against human MCF7 cells after 96 hrs by MTT assay	[PMID: 20022507]
MCF7	IC₅₀	7.1 μM Compound: 1	Antiproliferative activity against human MCF7 cells by MTT assay Antiproliferative activity against human MCF7 cells by MTT assay	[PMID: 23274571]
MDA-MB-231	IC₅₀	>10 μM Compound: 2	Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay Antiproliferative activity against human MDA-MB-231 cells after 96 hrs by MTT assay	[PMID: 20022507]
MDA-MB-231	IC₅₀	>40 μM Compound: 1	Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay Antimigratory activity against human MDA-MB-231 cells after 24 hrs by wound-healing assay	[PMID: 23274571]
MDA-MB-231	IC₅₀	9.4 μM Compound: 1	Antiproliferative activity against human MDA-MB-231 cells by MTT assay Antiproliferative activity against human MDA-MB-231 cells by MTT assay	[PMID: 23274571]

In Vitro

γ-Tocotrienol (25 μM; 24 h) effectively inhibits the expression levels of mdr1 mRNA and P-gp protein, (25 μM and 50 μM; 24 h) suppresses mdr1 promoter activity and the efflux activity of P-gp as well^[2].
γ-Tocotrienol (25 μM and 50 μM; 24 h) reduces the activation of NF-κB signaling pathway and the transcriptional activity of NF-κB^[2].
γ-tocotrienol (50 μM; 48 h) effectively inhibits the process of nuclear translocation of p65 which was induced by TNFα^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Immunofluorescence^[2]

Cell Line:

MCF-7/Adr cells
Concentration:

50 μM
Incubation Time:

48 hours
Result:

Decreased the red fluorescence of p65 in the nucleus, indicating nuclear translocation inhibiton of p65 induced by TNFα.

In Vivo

γ-Tocotrienol’s liposomal formulation, GT3-Nano (20 mol% γ-Tocotrienol), (10 mg/kg, 6 mol%; i.v.; single dose, observed for 100 d) is highly effective in mitigating the marrow-suppressive effects of sublethal and lethal TBI in mice^[3].
GT3-Nano (50 mg/kg; i.v.; ) can facilitate rapid recovery of hematopoietic components in mice treated with the endoradiotherapeutic agent ¹⁵³Sm-EDTMP^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

C57/BL6 mice (6-8 weeks old) treated with the whole-body irradiation^[3]
Dosage:

16, 24, 32, and 50 mg/kg
Administration:

Intravenous injection; observed mice for 100 days
Result:

Demonstrated dose-dependent radioprotection, achieving 90% survival at 50 mg/kg against lethal 9-Gy of total-body irradiation (TBI).
And upregulated progenitor bone marrow cells MPP2 and CMP in GT3-Nano-treated mice.

Chemical Information

CAS No. 14101-61-2
Appearance Liquid (Density: 0.964±0.06 g/cm³)
Molecular Weight 410.63
Formula C₂₈H₄₂O₂
Color Colorless to light yellow
SMILES

OC1=C(C)C(C)=C2C(CC[C@](CC/C=C(C)/CC/C=C(C)/CC/C=C(C)/C)(C)O2)=C1
Structure Classification
- Phenols
- Monophenols
Initial Source
- Plants
- other families
Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Publications (4)

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Journal Impact Factor

Int J Biol Macromol

Effects of altering the pullulan/zein ratio on emulsion electrospinning of palm tocotrienol. [Abstract]

2025 Sep 19;329(Pt 1):147791. PMID: 40976294
Food Biosci

2023 Aug, 54, 102888.
Iraqi Journal of Agricultural Sciences

2025.
Res Sq

2026 Jan 29.

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (243.53 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

2.4353 mL

12.1764 mL

24.3528 mL

5 mM

0.4871 mL

2.4353 mL

4.8706 mL

10 mM

0.2435 mL

1.2176 mL

2.4353 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Concentration Concentration

Volume Volume

Molecular Weight Molecular Weight

Dilution Calculator

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

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In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: 2.5 mg/mL (6.09 mM); Suspended solution; Need ultrasonic

This protocol yields a suspended solution of 2.5 mg/mL. Suspended solution can be used for oral and intraperitoneal injection.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.5 mg/mL (6.09 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

%
DMSO +

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
%
+
+
%
Tween-80 + +
%
Saline +

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Working solution concentration: 0.22 mg/mL

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (274 KB)
SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Portuguese - PT (393 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. M A Newaz, et al. Nitric Oxide Synthase Activity in Blood Vessels of Spontaneously Hypertensive Rats: Antioxidant Protection by Gamma-Tocotrienol. J Physiol Pharmacol. 2003 Sep;54(3):319-27. [Content Brief]

[2]. Ding Y, et al. γ-Tocotrienol reverses multidrug resistance of breast cancer cells through the regulation of the γ-Tocotrienol-NF-κB-P-gp axis. J Steroid Biochem Mol Biol. 2021 May;209:105835. [Content Brief]

[3]. Lee SG, et al. γ-Tocotrienol-Loaded Liposomes for Radioprotection from Hematopoietic Side Effects Caused by Radiotherapeutic Drugs. J Nucl Med. 2021 Apr;62(4):584-590. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
DMSO	1 mM	2.4353 mL	12.1764 mL	24.3528 mL	60.8821 mL
	5 mM	0.4871 mL	2.4353 mL	4.8706 mL	12.1764 mL
	10 mM	0.2435 mL	1.2176 mL	2.4353 mL	6.0882 mL
	15 mM	0.1624 mL	0.8118 mL	1.6235 mL	4.0588 mL
	20 mM	0.1218 mL	0.6088 mL	1.2176 mL	3.0441 mL
	25 mM	0.0974 mL	0.4871 mL	0.9741 mL	2.4353 mL
	30 mM	0.0812 mL	0.4059 mL	0.8118 mL	2.0294 mL
	40 mM	0.0609 mL	0.3044 mL	0.6088 mL	1.5221 mL
	50 mM	0.0487 mL	0.2435 mL	0.4871 mL	1.2176 mL
	60 mM	0.0406 mL	0.2029 mL	0.4059 mL	1.0147 mL
	80 mM	0.0304 mL	0.1522 mL	0.3044 mL	0.7610 mL
	100 mM	0.0244 mL	0.1218 mL	0.2435 mL	0.6088 mL

Keywords

γ-Tocotrienol

4 Cited Publications

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γ-Tocotrienol

Immunology/Inflammation Compound Library

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Publications Citing Use of MedChemExpress (MCE) γ-Tocotrienol

All Endogenous Metabolite Isoforms

All NF-κB Isoforms

Biological Activity

Chemical Information

Publications (4)

Solvent & Solubility

Purity & Documentation

References

Help & FAQs

Complete Stock Solution Preparation Table

γ-Tocotrienol Related Classifications

Cat. No.: HY-108694