15809-19-5
Chemical Structure
Myramistin
Synonym(s): Miramistin
- CAS No.: 15809-19-5
- Formula:C26H47ClN2O
- Molecular Weight:439.12
IUPAC Name: N-benzyl-N,N-dimethyl-3-tetradecanamidopropan-1-aminium chloride
InChIKey: JQQZCIIDNVIQKO-UHFFFAOYSA-N
SMILES: CCCCCCCCCCCCCC(NCCC[N+](C)(C)CC1=CC=CC=C1)=O.[Cl-]
Biological Activity: Myramistin (Miramistin) is a cationic surfactant and disinfectant preservative. Myramistin exhibits high bactericidal activity against Staphylococcus aureus and Escherichia coli, shows lower activity against yeasts and fungi, and is active against HIV, measles virus, mumps virus, as well as influenza viruses of the H3N2 and H5N1 subtypes. Myramistin adsorbs to the negatively charged microbial cell membrane, leading to increased membrane permeability and disruption of membrane integrity, which ultimately results in leakage of intracellular contents, enzyme inactivation, and the death of bacteria/fungi/enveloped viruses[1][2][3][4].
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Myramistin | 98.32% | Myramistin (Miramistin) is a cationic surfactant and disinfectant preservative. Myramistin exhibits high bactericidal activity against Staphylococcus aureus and Escherichia coli, shows lower activity against yeasts and fungi, and is active against HIV, measles virus, mumps virus, as well as influenza viruses of the H3N2 and H5N1 subtypes. Myramistin adsorbs to the negatively charged microbial cell membrane, leading to increased membrane permeability and disruption of membrane integrity, which ultimately results in leakage of intracellular contents, enzyme inactivation, and the death of bacteria/fungi/enveloped viruses. | ||||||||||||||||||||
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Myramistin (Standard) | ≥98% | Myramistin (Miramistin) (Standard) is the analytical standard of Myramistin (HY-103658). This product is intended for research and analytical applications. Myramistin is a cationic surfactant and disinfectant preservative. Myramistin exhibits high bactericidal activity against Staphylococcus aureus and Escherichia coli, shows lower activity against yeasts and fungi, and is active against HIV, measles virus, mumps virus, as well as influenza viruses of the H3N2 and H5N1 subtypes. Myramistin adsorbs to the negatively charged microbial cell membrane, leading to increased membrane permeability and disruption of membrane integrity, which ultimately results in leakage of intracellular contents, enzyme inactivation, and the death of bacteria/fungi/enveloped viruses. | ||||||||||||||||||||
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- [1]. Kryvorutchenko IuL, et al. Antiseptic myramistin possesses the strong anti-HIV properties. Mikrobiolohichnyi zhurnal (Kiev, Ukraine : 1993). 1996;58(5):90-2. [Content Brief]
- [2]. Vertelov GK, et al. A versatile synthesis of highly bactericidal Myramistin® stabilized silver nanoparticles. Nanotechnology. 2008 Sep 03;19(35):355707. [Content Brief]
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[3]. Agafonov AP, et al. In vitro study of antiviral activity of Myramistin against measles and mumps viruses. Antibiot Khimioter. 2005;50(5-6):17-9. Russian.
[Content Brief] - [4]. Agafonova MN, et al. Antibacterial activity profile of miramistin in in vitro and in vivo models. Microbial pathogenesis. 2020 May;142:104072. [Content Brief]
Keywords
