2241813-33-0
2241813-33-0
Chemical Structure
DDR1/2 inhibitor-3
- CAS No.: 2241813-33-0
- Formula:C31H31F3N6O
- Molecular Weight:560.61
IUPAC Name: 3-(imidazo[1,2-a]pyrazin-3-ylethynyl)-4-isopropyl-N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide
InChIKey: IUGBGEUCXVKGQK-UHFFFAOYSA-N
SMILES: O=C(NC1=CC(C(F)(F)F)=CC(CN2CCN(C)CC2)=C1)C3=CC=C(C(C)C)C(C#CC4=CN=C5C=NC=CN54)=C3
Biological Activity: DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC50 valuesof 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research[1].
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DDR1/2 inhibitor-3 | DDR1/2 inhibitor-3 (5n) is a DDR1/2 inhibitor, with IC50 valuesof 9.4 and 20.4 nM, respectively. DDR1/2 inhibitor-3 can be used in anti-inflammatory research. | |||||||||||||||||||||
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References
- [1]. Wang Z, et al. Design, Synthesis, and Biological Evaluation of 3-(Imidazo[1,2- a]pyrazin-3-ylethynyl)-4-isopropyl- N-(3-((4-methylpiperazin-1-yl)methyl)-5-(trifluoromethyl)phenyl)benzamide as a Dual Inhibitor of Discoidin Domain Receptors 1 and 2. J Med Chem. 2018 Sep 13;61(17):7977-7990. [Content Brief]
Keywords
