298-57-7
Chemical Structure
Cinnarizine
- CAS No.: 298-57-7
- Formula:C26H28N2
- Molecular Weight:368.51
IUPAC Name: 1-benzhydryl-4-cinnamylpiperazine
InChIKey: DERZBLKQOCDDDZ-JLHYYAGUSA-N
SMILES: N1(C(C2=CC=CC=C2)C3=CC=CC=C3)CCN(C/C=C/C4=CC=CC=C4)CC1
Biological Activity: Cinnarizine is an orally active, effective and selective inhibitor of L-type calcium channel Cav1.3 with an IC50 of 1.5 μM (in vestibular hair cells). Cinnarizine can cross the blood-brain barrier and regulate calcium homeostasis and dopamine neurotransmission. Cinnarizine inhibits the influx of calcium ions into smooth muscle cells by blocking L-type calcium channels, thereby relaxing vascular smooth muscle, improving cerebral circulation and reducing blood viscosity, while antagonizing dopamine receptors. Cinnarizine can be used in the study of vestibular vertigo, Meniere's disease and cerebrovascular diseases[1][2][3][4][5].
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Cinnarizine | 99.56% | Cinnarizine is an orally active, effective and selective inhibitor of L-type calcium channel Cav1.3 with an IC50 of 1.5 μM (in vestibular hair cells). Cinnarizine can cross the blood-brain barrier and regulate calcium homeostasis and dopamine neurotransmission. Cinnarizine inhibits the influx of calcium ions into smooth muscle cells by blocking L-type calcium channels, thereby relaxing vascular smooth muscle, improving cerebral circulation and reducing blood viscosity, while antagonizing dopamine receptors. Cinnarizine can be used in the study of vestibular vertigo, Meniere's disease and cerebrovascular diseases. | ||||||||||||||||||||
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Cinnarizine (Standard) | 99.01% | Cinnarizine (Standard) is the analytical standard of Cinnarizine. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Cinnarizine-d8 | 98.24% | Cinnarizine-d8 is a deuterium labeled Cinnarizine. Cinnarizine is an antihistamine and a calcium channel blocker. | ||||||||||||||||||||
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- [1]. Arab SF, et al. Inhibition of voltage-gated calcium currents in type II vestibular hair cells by cinnarizine. Naunyn Schmiedebergs Arch Pharmacol. 2004 Jun;369(6):570-5. [Content Brief]
- [2]. Düwel P, et al. Effects of cinnarizine on calcium and pressure-dependent potassium currents in guinea pig vestibular hair cells. Naunyn Schmiedebergs Arch Pharmacol. 2005 Jun;371(6):441-8. [Content Brief]
- [3]. Ng E, et al. Evaluation of Aldosterone Suppression by Cinnarizine, a Putative Cav1.3 Inhibitor. J Clin Endocrinol Metab. 2025 Feb 10:dgaf081. [Content Brief]
- [4]. Serrano A, et al. Effects of cinnarizine, a calcium antagonist that produces human parkinsonism, in parkin knock out mice. Neuropharmacology. 2005 Aug;49(2):208-19. [Content Brief]
- [5]. Li BQ, et al. Effect of route of administration on the pharmacokinetics and toxicokinetics of cinnarizine in dogs. Eur J Pharm Sci. 2010 Jun 14;40(3):197-201. [Content Brief]
