466-61-5
Chemical Structure
Lycopodine
- CAS No.: 466-61-5
- Formula:C16H25NO
- Molecular Weight:247.38
IUPAC Name: (1S,8aR,9S,11R,12aR)-11-methyldodecahydro-1,9-ethanopyrido[2,1-j]quinolin-14-one
InChIKey: BCZFSDNVXODRAJ-JTTNIQEDSA-N
SMILES: O=C1[C@]2([H])[C@]34[C@@](CCCN4CCC2)([H])[C@](C[C@@H](C)C3)([H])C1
Biological Activity: Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity[1]. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation[2].
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Lycopodine | Lycopodine, a pharmacologically important bioactive component derived from Lycopodium clavatumspores, triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in refractory prostate cancer cells without modulating p53 activity. Lycopodine inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. | |||||||||||||||||||||
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References
- [1]. Bishayee K, et al. Lycopodine triggers apoptosis by modulating 5-lipoxygenase, and depolarizing mitochondrial membrane potential in androgen sensitive and refractory prostate cancer cells without modulating p53 activity: signaling cascade and drug-DNA interaction. Eur J Pharmacol. 2013 Jan 5;698(1-3):110-21. [Content Brief]
- [2]. Mandal SK, et al. Lycopodine from Lycopodium clavatum extract inhibits proliferation of HeLa cells through induction of apoptosis via caspase-3 activation. Eur J Pharmacol. 2010 Jan 25;626(2-3):115-22. [Content Brief]
