480-26-2
Chemical Structure
Cryptolepine
- CAS No.: 480-26-2
- Formula:C16H12N2
- Molecular Weight:232.29
IUPAC Name: 5-methyl-5H-indolo[3,2-b]quinoline
InChIKey: KURWKDDWCJELSV-UHFFFAOYSA-N
SMILES: N1=C2C=CC=CC2=C3C1=CC=4C=CC=CC4N3C
Biological Activity: Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection[1][2][3][4][6][7][8][9][10][11][12][13][14].
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Cryptolepine | Cryptolepine is an orally active multi-potent alkaloid with anti-cancer, anti-bacterial, anti-viral, anti-malarial, anti-inflammatory, anti-hyperglycemic, relieve pain and other properties. Cryptolepine acts as an inhibitor of c-Myc, mTOR, NF-κB, HIF-1, MAPK and an activator of AMPKα1/2. It intercalates into DNA, inhibits topoisomerase II (Top II), disrupts mitochondrial dynamics and induces apoptosis. Cryptolepine also exhibits anti-plasmodial and cholinesterase inhibitory activities. Cryptolepine can be used in research related to tumors (melanoma, hepatocellular carcinoma, mammary adenocarcinoma, etc.), malaria, inflammatory diseases and diabetes, particularly in studies focused on inhibiting tumor growth and anti-plasmodial infection. | |||||||||||||||||||||
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- [1]. Pal HC, et al. Cryptolepine inhibits melanoma cell growth through coordinated changes in mitochondrial biogenesis, dynamics and metabolic tumor suppressor AMPKα1/2-LKB1. Sci Rep. 2017;7(1):1498. Published 2017 May 4. [Content Brief]
- [2]. Ferguson G, et al. Computational Insight into the Intercalating Properties of Cryptolepine. ACS Omega. 2025;10(18):18283-18290. Published 2025 Apr 28. [Content Brief]
- [3]. Kirby G C, et al. In vitro and in vivo antimalarial activity of cryptolepine, a plant‐derived indoloquinoline[J]. Phytotherapy research, 1995, 9(5): 359-363.
- [4]. Tudu CK, et al. Unravelling the pharmacological properties of cryptolepine and its derivatives: a mini-review insight. Naunyn Schmiedebergs Arch Pharmacol. 2023;396(2):229-238. [Content Brief]
- [6]. Domfeh SA, et al. Cryptolepine inhibits hepatocellular carcinoma growth through inhibiting interleukin-6/STAT3 signalling. BMC Complement Med Ther. 2021;21(1):161. Published 2021 Jun 2. [Content Brief]
- [7]. Olajide OA, et al. Anti-inflammatory properties of cryptolepine. Phytother Res. 2009;23(10):1421-1425. [Content Brief]
- [8]. Zheng Z, et al. Cryptolepine suppresses breast adenocarcinoma via inhibition of HIF-1 mediated glycolysis. Biomed Pharmacother. 2022;153:113319. [Content Brief]
- [9]. Amissah JN, et al. Mineral Fertilization Influences the Growth, Cryptolepine Yield, and Bioefficacy of Cryptolepis sanguinolenta (Lindl.) Schlt. Plants (Basel). 2022;11(1):122. Published 2022 Jan 1. [Content Brief]
- [10]. Domfeh SA, et al. The Pharmacologically Active Alkaloid Cryptolepine Activates a Type 1 Interferon Response That Is Independent of MAVS and STING Pathways. J Immunol Res. 2022;2022:8873536. Published 2022 Jul 26. [Content Brief]
- [11]. Amissah JN, et al. Increasing the planting density of Cryptolepis sanguinolenta (Lindl.) Schlt increased root biomass and cryptolepine yield. Heliyon. 2024;10(10):e30932. Published 2024 May 9. [Content Brief]
- [12]. Forkuo AD, et al. In vitro anti-malarial interaction and gametocytocidal activity of cryptolepine. Malar J. 2017;16(1):496. Published 2017 Dec 28. [Content Brief]
- [13]. Quarshie JT, et al. Cryptolepine Suppresses Colorectal Cancer Cell Proliferation, Stemness, and Metastatic Processes by Inhibiting WNT/β-Catenin Signaling. Pharmaceuticals (Basel). 2023;16(7):1026. Published 2023 Jul 19. [Content Brief]
Keywords
