486-16-8
Chemical Structure
(±)-Carbinoxamine
- CAS No.: 486-16-8
- Formula:C16H19ClN2O
- Molecular Weight:290.79
IUPAC Name: 2-((4-chlorophenyl)(pyridin-2-yl)methoxy)-N,N-dimethylethan-1-amine
InChIKey: OJFSXZCBGQGRNV-UHFFFAOYSA-N
SMILES: CN(CCOC(C1=CC=CC=N1)C2=CC=C(C=C2)Cl)C
Biological Activity: (±)-Carbinoxamine is a blood-brain barrier-permeable histamine H1 receptor antagonist. (±)-Carbinoxamine blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. (±)-Carbinoxamine inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. (±)-Carbinoxamine can be used in research on allergic rhinitis, influenza, etc.[1][2]
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(±)-Carbinoxamine | (±)-Carbinoxamine is a blood-brain barrier-permeable histamine H1 receptor antagonist. (±)-Carbinoxamine blocks the action of histamine on H1 receptors, reducing symptoms such as sneezing, rhinitis, rhinorrhea, erythema, pruritus and urticaria. (±)-Carbinoxamine inhibits influenza virus entry into cells via endocytosis, targets the early stage of the viral life cycle, and simultaneously reduces viral replication levels in the lungs, alleviating pathological damage and inflammatory responses in lung tissues. (±)-Carbinoxamine can be used in research on allergic rhinitis, influenza, etc. | |||||||||||||||||||||
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- [1]. Xu W, et al. The Antihistamine Drugs Carbinoxamine Maleate and Chlorpheniramine Maleate Exhibit Potent Antiviral Activity Against a Broad Spectrum of Influenza Viruses. Front Microbiol. 2018;9:2643. Published 2018 Nov 6. [Content Brief]
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[2]. Garat BR, et al. Clinical, chemical, and pharmacologic relationships of antihistamines: A study of a new synthetic antihistaminic, carbinoxamine maleate (Clistin maleate). Journal of Allergy. 1956 Jan 1;27(1):57-62.
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