618-39-3
618-39-3
Chemical Structure
Benzamidine
- CAS No.: 618-39-3
- Formula:C7H8N2
- Molecular Weight:120.15
IUPAC Name: benzimidamide
InChIKey: PXXJHWLDUBFPOL-UHFFFAOYSA-N
SMILES: N=C(C1=CC=CC=C1)N
Biological Activity:
Benzamidine is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Benzamidine | 95.0% | Benzamidine is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results. |
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Benzothiohydrazide | 99.72% | Benzothiohydrazide is an analogue of anti–tubercular agent Isoniazid. Benzothiohydrazide exhibits anti–tubercular activity, with MICs of 132 μM and 264 μM for M. tuberculosis wild type (H37Rv) and clinical mutant strains (IC1 and IC2). | ||||||||||||||||||||
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Benzoic acid | 99.95% | Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi. | ||||||||||||||||||||
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Benzoic acid-13C6 | 99.66% | Benzoic acid-13C6 is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi. | ||||||||||||||||||||
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Benzoic acid-13C | 98% | Benzoic acid-13C is the 13C-labeled Benzoic acid. Benzoic acid is an aromatic alcohol existing naturally in many plants and is a common additive to food, drinks, cosmetics and other products. It acts as preservatives through inhibiting both bacteria and fungi. | ||||||||||||||||||||
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Benzoic acid-13C7 | Benzoic acid-13C7 is the 13C-labeled Benzoic acid (HY-N0216). Benzoic acid is an aromatic alcohol existing naturally in many?plants?and is a common additive to food, drinks, cosmetics and?other?products. It acts as?preservatives?through inhibiting both?bacteria?and?fungi. | |||||||||||||||||||||
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Nicotinimidamide hydrochloride | 99.26% | Nicotinimidamide hydrochloride is a drug intermediate for synthesis of various active compounds. | ||||||||||||||||||||
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Benzohydrazide (Standard) | 98.67% | Benzohydrazide (Standard) is the analytical standard of Benzohydrazide. This product is intended for research and analytical applications. | ||||||||||||||||||||
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Benzamidine hydrochloride (Standard) | ≥98% | Benzamidine hydrochloride (Standard) is the analytical standard of Benzamidine (hydrochloride). This product is intended for research and analytical applications. Benzamidine hydrochloride is a competitive protease inhibitor that blocks the hydrolytic cleavage of glucagon by plasmin, trypsin and thrombin. Benzamidine hydrochloride effectively inhibits the degradation of glucagon by relevant proteases during the collection, storage and analysis of human plasma and blood samples. During in vivo metabolism, Benzamidine hydrochloride undergoes N-hydroxylation and produces multiple metabolites, exhibiting characteristics of delayed excretion or biphasic elimination. Benzamidine hydrochloride only induces slight single-strand DNA breaks at high concentrations and shows no significant genotoxic potential overall. Benzamidine hydrochloride may interfere with the detection of some glucagon antisera, but does not affect key antigen-antibody affinity at specific concentrations. Benzamidine hydrochloride can be used as a stabilizer in glucagon radioimmunoassays to ensure the accuracy and recovery rate of detection results. | ||||||||||||||||||||
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Benzamide | 99.74% | Benzamide (Benzenecarboxamide) is a potent poly(ADP-ribose) polymerase (PARP) inhibitor. Benzamide has protective activity against both glutamate- and methamphetamine (METH)-induced neurotoxicity in vitro. Benzamide can attenuate the METH-induced dopamine depletions and exhibits neuroprotective activity in mice, also has no acute effect on striatal dopamine metabolism and does not reduce body temperature. | ||||||||||||||||||||
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Benzamide-15N | 99.87% | Benzamide-15N is a 15N-labeled Benzamide. Benzamide inhibits poly(ADP-ribose) polymerase (PARP). | ||||||||||||||||||||
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References
- [1]. ENSINCK J W, et al. Use of benzamidine as a proteolytic inhibitor in the radioimmunoassay of glucagon in plasma[J]. The Journal of Clinical Endocrinology & Metabolism, 1972, 35(3): 463-467.
- [2]. Clement B, et al. Genotoxic activities of benzamidine and its N-hydroxylated metabolite benzamidoxime in Salmonella typhimurium and mammalian cells. J Cancer Res Clin Oncol. 1988;114(4):363-368. [Content Brief]
- [3]. Clement B, et al. Biotransformation of benzamidine and benzamidoxime in vivo. Arch Pharm (Weinheim). 1993;326(10):807-812. [Content Brief]
