69770-45-2
69770-45-2
Chemical Structure
Flumethrin
Synonym(s): FCR 2769
- CAS No.: 69770-45-2
- Formula:C28H22Cl2FNO3
- Molecular Weight:510.38
IUPAC Name: cyano(4-fluoro-3-phenoxyphenyl)methyl (Z)-3-(2-chloro-2-(4-chlorophenyl)vinyl)-2,2-dimethylcyclopropane-1-carboxylate
InChIKey: YXWCBRDRVXHABN-JCMHNJIXSA-N
SMILES: N#CC(C1=CC=C(C(OC2=CC=CC=C2)=C1)F)OC(C3C(C3(C)C)/C=C(C4=CC=C(C=C4)Cl)\Cl)=O
Biological Activity: Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer[1][2][3][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Flumethrin | 99.29% | Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer. | ||||||||||||||||||||
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Flumethrin (Standard) | ≥98% | Flumethrin (Standard) (FCR 2769 (Standard)) is the analytical standard of Flumethrin (HY-107835). This product is intended for research and analytical applications. Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer. | ||||||||||||||||||||
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Flumethrin-d5 | Flumethrin-d5 (FCR 2769-d5) is the deuterium labeled Flumethrin (HY-107835). Flumethrin (FCR 2769) is a pyrethroid insecticide and acaricide. Flumethrin targets voltage-gated sodium channels and estrogen receptor α (ERα). Flumethrin induces cytotoxicity, apoptosis, genotoxicity and DNA damage in breast cancer cells by regulating the expression of BCL2, BAX, TP53 and P21 genes. Flumethrin is applicable to relevant studies on ectoparasite infections (tick and flea burdens) in dogs and cats, as well as breast cancer. | |||||||||||||||||||||
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Cyhalothrin | 99.25% | Cyhalothrin is a pyrethroid, a class of man-made insecticides that mimic the structure and insecticidal properties of the naturally-occurring insecticide pyrethrum which comes from the flowers of chrysanthemums. | ||||||||||||||||||||
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Alpha-Cypermethrin | 99.66% | Alpha-Cypermethrin (FMC 45497; Fendona; WL 85871) is a type II pyrethroid insecticide. Alpha-Cypermethrin acts by delaying the inactivation of voltage-gated sodium channels, prolonging sodium tail currents, and triggering repetitive neural discharges. Alpha-Cypermethrin exhibits knockdown and lethal activity against target insects such as Musca domestica and Anopheles culicifacies. Alpha-Cypermethrin induces neurotoxicity in mammals, alters placental and fetal neurodevelopment, and causes acute mortality in fish. Alpha-Cypermethrin can be used in studies related to neurotoxicity, vector-borne diseases, and malaria. | ||||||||||||||||||||
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Cyfluthrin | 99.52% | Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product. | ||||||||||||||||||||
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β-Cyfluthrin | 99.94% | β-Cyfluthrin (beta-Cyfluthrin) is a type II synthetic pyrethroid and also an active ingredient of many insecticide products used for pestsin agriculture. β-Cyfluthrin is a neurotoxicant and affects calcium concentration in nervous tissue by inhibiting Ca2+ ATPase involved in calcium transport. | ||||||||||||||||||||
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Cyfluthrin-d6 | Cyfluthrin-d6 (β-Cyfluthi-d6) is deuterium labeled Cyfluthrin. Cyfluthrin is a type II pyrethroid and has effects on various insects. Cyfluthrin is a modulator of Nav1.8 sodium channels by repetitive stimulation. Cyfluthrin can be applied in agriculture,veterinary, insecticide,pyrethroid and stored product. | |||||||||||||||||||||
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(1R,2S,1'R)-Cypermethrin | (1R,2S,1'R)-Cypermethrin is an isomer of Cypermethrin (HY-B0829). Cypermethrin is a Class II pyrethroid pesticide with oral activity and blood-brain barrier permeability. | |||||||||||||||||||||
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Zeta-Cypermethrin | Zeta-Cypermethrin is a type II pyrethroid insecticide. Zeta-Cypermethrin primarily acts on voltage-gated sodium channels in nerve cells, causing delayed channel closure, persistent nerve excitation and convulsions. In Drosophila, Zeta-Cypermethrin rapidly induces extremely high metabolic resistance that can be screened, and exhibits in vitro genotoxicity to human peripheral blood lymphocytes. | |||||||||||||||||||||
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(+)-Theta-cypermethrin | (+)-Theta-cypermethrin is a stereoisomer of Cypermethrin (HY-B0829) that possesses blood-brain barrier penetration ability and binds to AKT1, SRC, STAT3 and EGFR with high affinity. (+)-Theta-cypermethrin reduces the amplitude of delayed rectifier potassium channel currents, shifts the steady-state activation curve to negative potentials, and shifts the steady-state inactivation curve to negative potentials at higher concentrations. (+)-Theta-cypermethrin induces abnormal electrical activity in rat hippocampal neurons. (+)-Theta-cypermethrin causes chronic respiratory system damage and exhibits neurotoxicity. | |||||||||||||||||||||
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γ-Cyhalothrin | γ-Cyhalothrin is an orally active, blood-brain barrier permeable Type II synthetic pyrethroid insecticide. γ-Cyhalothrin is the insecticidally active enantiomer of λ-Cyhalothrin (HY-B0836). γ-Cyhalothrin disrupts voltage-gated sodium channels, induces salivation and reduces spontaneous activity in rats. γ-Cyhalothrin exerts toxic effects on aquatic invertebrates and fish, triggers community-level effects in aquatic ecosystems, and inhibits host-seeking Ixodes scapularis nymphs in residential lawn ecotones. γ-Cyhalothrin is applicable to insecticidal-related research. | |||||||||||||||||||||
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References
- [1]. Stanneck D, et al. The synergistic action of imidacloprid and flumethrin and their release kinetics from collars applied for ectoparasite control in dogs and cats. Parasit Vectors. 2012;5:73. Published 2012 Apr 12. [Content Brief]
- [2]. Kara-Ertekin S, et al. In vitro toxicological assessment of flumethrin's effects on MCF-7 breast cancer cells. Hum Exp Toxicol. 2021;40(12):2165-2177. [Content Brief]
- [3]. Qi S, et al. Flumethrin at sublethal concentrations induces stresses in adult honey bees (Apis mellifera L.). Sci Total Environ. 2020;700:134500. [Content Brief]
- [4]. Başçi Z, et al. Toxicokinetic of flumethrin in rabbits. Drug Chem Toxicol. 2015;38(1):92-97. [Content Brief]
