77-86-1
77-86-1
Chemical Structure
THAM
Synonym(s): Tris; Tris(hydroxymethyl)aminomethane
- No. CAS: 77-86-1
- Formula:C4H11NO3
- Molecular Weight:121.14
IUPAC Name: 2-amino-2-(hydroxymethyl)propane-1,3-diol
InChIKey: LENZDBCJOHFCAS-UHFFFAOYSA-N
SMILES: OCC(CO)(N)CO
Biological Activity: THAM (Tris) is a low-toxicity amino alcohol buffer, a specific CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications[1][2][3][4][5].
| Referencia número | Nombre del producto | Pureza | Descripciòn | Pricing | |||||||||||||||||||
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THAM | 99.88% | THAM (Tris) is a low-toxicity amino alcohol buffer, a specific CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications. | ||||||||||||||||||||
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THAM (Standard) | ≥98% | THAM (Standard) is the analytical standard of THAM. This product is intended for research and analytical applications. THAM (Tris) is a biologically inert amino alcohol of low toxicity, which buffers carbon dioxide and acids in vitro and in vivo. THAM is an effective amine compound for pH control in the physiological range. | ||||||||||||||||||||
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THAM-d11 (for molecular biology) | 99.88% | Trometamol(Tris),for molecular biology-d11 is the deuterium labeled Trometamol(Tris),for molecular biology. | ||||||||||||||||||||
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Loprodiol | Loprodiol is a dichlorinated derivative of pentaerythritol, formed as a side product during pentaerythritol chlorination for BAMO synthesis. | |||||||||||||||||||||
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Glycerol-13C3,d8 | Glycerol-13C3,d8 is the deuterium and 13C labeled Glycerol. | |||||||||||||||||||||
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THAM acetate | 97.0% | THAM acetate is a low-toxicity amino alcohol buffer, a CO2-consuming proton acceptor that buffers carbon dioxide and acid both in vitro and in vivo. THAM acetate binds protons to form bicarbonate, reduces PaCO2, and induces intracellular alkalization, thereby ameliorating hypercapnia-induced elevation of pulmonary blood vessels and pulmonary arterial pressure. THAM acetate may cause PaCO2 rebound, hypoglycemia, and respiratory depression. THAM acetate removes amniotic epithelium and preserves the basement membrane, but depletes extracellular matrix and reduces the adhesion rate of limbal epithelial cells. THAM acetate can act as a CO2 carrier to enhance the productivity and carbon utilization rate of Scenedesmus obliquus. THAM acetate is a key component of buffer solutions used in various biological, cell culture, biochemical, and molecular biology applications. | ||||||||||||||||||||
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THAM hydrochloride (≥99%, reagent grade) | 99.80% | THAM hydrochloride (≥99%, reagent grade), also known as Tris-HCl, is a buffer commonly used in various biochemical and molecular biology applications to maintain a stable pH environment. Tris-HCl has unique chemical properties that allow it to resist changes in pH when acidic or basic substances are added, which makes it useful for stabilizing biological samples or reagents. It is commonly used in electrophoresis and protein purification procedures. | ||||||||||||||||||||
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Bis-Tris-d19 | 99% | Bis-Tris-d19 is the deuterium labeled Bis-Tris. Bis-Tris is a commonly used buffer. | ||||||||||||||||||||
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Tricine | 99.89% | Tricine is widely used as a buffer in protein electrophoresis, nucleic acid analysis, and immunology, which can help adjust pH and stabilize chemical reactions. In addition, the compound can also be used in research in certain medical fields, such as in antibody detection and drug screening. | ||||||||||||||||||||
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L-Serine-d7 | 99.97% | L-Serine-d7 is the deuterium labeled L-Serine. L-Serine ((-)-Serine; (S)-Serine), one of the so-called non-essential amino acids, plays a central role in cellular proliferation. | ||||||||||||||||||||
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2-Amino-2-methyl-1-propanol-d11 | 2-Amino-2-methyl-1-propanol-d11 is the deuterium labeled 2-Amino-2-methyl-1-propanol. | |||||||||||||||||||||
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2-Amino-2-methyl-1,3-propanediol | 98.0% | 2-Amino-2-methyl-1,3-propanediol is a solid-solid phase change material with energy release and heat storage properties. 2-Amino-2-methyl-1,3-propanediol can crystallize from a supercooled solid state, release thermal energy during heating, and store thermal energy in the supercooled solid state. 2-Amino-2-methyl-1,3-propanediol can be used in the production of surfactants, vulcanization accelerators, and as a biological buffer. | ||||||||||||||||||||
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Tris(hydroxymethyl)nitromethane | Tris (hydroxymethyl) nitromethane is a fungicide and slime control agent. Tris (hydroxymethyl) nitromethane exhibits cytotoxicity against EBV-transformed human Burkitt's lymphoma cells. Tris (hydroxymethyl) nitromethane also serves as an important raw material and intermediate in organic synthesis. | |||||||||||||||||||||
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1,3-Propanediol-d8 | 98.9% | 1,3-Propanediol-d8 is the deuterium labeled 1,3-Propanediol. 1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism. | ||||||||||||||||||||
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Propan-2-amine-d9 hydrochloride | 99% | Propan-2-amine-d9 (hydrochloride) is the deuterium labeled Propan-2-amine hydrochloride. | ||||||||||||||||||||
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Glycerol-d8 | 99.98% | Glycerol-d8 is the deuterium labeled Glycerol. | ||||||||||||||||||||
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Tris(hydroxymethyl)methylammonium dihydrogen phosphate | Tris(hydroxymethyl)methylammonium dihydrogen phosphate is a biochemical assay reagent. | |||||||||||||||||||||
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Prenderol | 99.85% | Prenderol is a potent central-nervous-system depressant. Prenderol has anticonvulsant activity. | ||||||||||||||||||||
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Tris hemisulfate,98% | Tris hemisulfate,98% is a biochemical assay reagent. | |||||||||||||||||||||
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Tris phosphate dibasic | Tris phosphate dibasic is a biochemical assay reagent. | |||||||||||||||||||||
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Ethylene Glycol-d6 | 99.95% | Ethylene Glycol-d6 is the deuterium labeled Ethylene glycol. | ||||||||||||||||||||
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(±)-1,2-Propanediol-d8 | 99.55% | (±)-1,2-Propanediol-d8 is the deuterium labeled (±)-1,2-Propanediol. (±)-1,2-Propanediol (1,2-(RS)-Propanediol) is an aliphatic alcohol and frequently used as an excipient in many agent formulations to increase the solubility and stability of agents. | ||||||||||||||||||||
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References
- [1]. Nahas GG, et al. Guidelines for the treatment of acidaemia with THAM. Drugs. 1998 Feb;55(2):191-224. [Content Brief]
- [2]. Höstman S, et al. THAM reduces CO2-associated increase in pulmonary vascular resistance - an experimental study in lung-injured piglets. Crit Care. 2015 Sep 17;19(1):331. [Content Brief]
