1. Anti-infection
  2. Bacterial
    Antibiotic
  3. Cefodizime sodium

Cefodizime sodium 

Cat. No.: HY-108402A Purity: 99.35%
Handling Instructions

Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts.

For research use only. We do not sell to patients.

Cefodizime sodium Chemical Structure

Cefodizime sodium Chemical Structure

CAS No. : 86329-79-5

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Free Sample (0.5-1 mg)   Apply Now  
10 mM * 1  mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
50 mg USD 80 In-stock
Estimated Time of Arrival: December 31
100 mg USD 110 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Cefodizime sodium is a third generation cephalosporin antibiotic with a broad spectrum of antibacterial activity. Cefodizime sodium has no renal toxic effect, good tolerance and immune regulation activity, and can be used for the research of severe infections of the respiratory and urinary tracts[1][2].

IC50 & Target

Bacterial[1]

In Vitro

Enterobacteriaceae including Escherichia coli, Klebsiella pneumoniae, Morganella morgan ii, Proteus mirabilis, Proteus vulgaris, Shigella sonnei, Yersinia enterocolitica and Salmonella species are all consistently sensitive to Cefodizime in vitro. Cefodizime has marginal but variable inhibitory activity against Citrobacter species including Citrobacter freundii, and Serratia marcescens. Cefodizime inhibits other Gram-negative bacteria including Haemophilus irifluenzae, Moraxella catarrhalis, Neisseria gonorrhoeae and Neisseria meningitidis[1].
Cefodizime is a bactericidal antibiotic having high affinity for penicillin-binding proteins lA/B, 2 and 3 of E. coli. The in vitro concentrations of Cefodizime resulting in bactericidal activity against susceptible strains of Gram-positive and Gram-negative bacteria are generally similar to the minimum inhibitory concentrations[1].

In Vivo

In experimentally-induced K. pneumoniae respiratory tract infections in mice, Cefodizime has activity comparable to Cefotaxime and Ceftazidime, and greater than that of Cefoperazone, Latamoxef, Cefuroxime or cefazolin for 8 hours after a single subcutaneous dose of 50 mg/kg. However, unlike these cephalosporins, Cefodizime continues to demonstrate pronounced bactericidal activity for at least 48 hours after a single injection. Complete bacterial clearance from the lung is achieved within 48 hours in 50% of the mice although Cefodizime is no longer detectable in the serum[1].

Molecular Weight

628.63

Formula

C₂₀H₁₈N₆Na₂O₇S₄

CAS No.

86329-79-5

SMILES

O=C(C(N12)=C(CSC3=NC(C)=C(CC(O[Na])=O)S3)CS[[email protected]]2([H])[[email protected]](NC(/C(C4=CSC(N)=N4)=N\OC)=O)C1=O)O[Na]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (99.42 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5908 mL 7.9538 mL 15.9076 mL
5 mM 0.3182 mL 1.5908 mL 3.1815 mL
10 mM 0.1591 mL 0.7954 mL 1.5908 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 2.08 mg/mL (3.31 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 2.08 mg/mL (3.31 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

CefodizimeBacterialAntibioticbroadspectrumrespiratoryurinarytractsGram-positiveGram-negativeInhibitorinhibitorinhibit

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Product Name:
Cefodizime sodium
Cat. No.:
HY-108402A
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