Art. -Nr.: HY-N0289

Lycorine hydrochloride

Name: Lycorine hydrochloride
Brand: MedChemExpress
SKU: HY-N0289
Price: 50.00 USD
Availability: InStock
Rating: 5 (24 reviews)

24 Cited Publications

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Based on 24 publication(s) in Google Scholar

Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC₅₀ of 1.2 μM).

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Reinheit: 98.19%
CAS. Nr.: 2188-68-3
Formel: C₁₆H₁₈ClNO₄
Molecular Weight:323.77

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Lycorine hydrochloride Chemical Structure

CAS. Nr.: 2188-68-3

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Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Publications (24)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

Lycorine hydrochloride is the main active ingredient of the herbal medicine derived from Lycoris radiata (L’Her.) Herb. and is also a melanoma vasculogenic inhibitor and has anti-tumor activity^[1]. Lycorine hydrochloride effectively inhibits mitotic proliferation of Hey1B cells (IC₅₀ of 1.2 μM)^[2].

IC₅₀ & Target

IC50: 1.2 μM (Hey1B cells )^[2]

In Vitro

Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly suppresses the expression of vascular endothelial (VE)-cadherin in a dose-dependent manner and also slightly diminishes the expression of Sema4D in C8161 cells. However, the expression of the other six genes is not affected^[1].
Lycorine hydrochloride (0-25 μM; 48 hours; C8161 cells) treatment markedly reduces VE-cadherin protein levels in C8161 cells in a dose-dependent fashion^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:

C8161 cells
Concentration:

0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time:

48 hours
Result:

Markedly suppressed the expression of VE-cadherin in a dose-dependent manner and also slightly diminished the expression of Sema4D in C8161 cells.

Western Blot Analysis^[1]

Cell Line:

C8161 cells
Concentration:

0 μM, 1.56 μM, 3.13 μM, 6.25 μM, 12.5 μM, 25 μM
Incubation Time:

48 hours
Result:

Markedly reduced VE-cadherin protein levels in C8161 cells in a dose-dependent fashion.

In Vivo

Lycorine hydrochloride (0-15 μg; subcutaneous injection; for 14 days; BALB/C nude mice) treatment has an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

6- to 8-week-old BALB/C nude mice^[1]
Dosage:

0 μg, 7.5 μg, 15 μg
Administration:

Subcutaneous injection; for 14 days
Result:

Showed an inhibitory effect on melanoma cell-mediated tumor vasculogenic mimicry.

Chemical Information

CAS. Nr. 2188-68-3
Appearance Solid
Molecular Weight 323.77
Formel C₁₆H₁₈ClNO₄
Color White to off-white
SMILES

O[C@@H]1[C@@H](O)C=C(CC2)[C@@]3([H])N2CC4=C([C@@]31[H])C=C(OCO5)C5=C4.Cl
Structure Classification
- Alkaloids
- Isoquinoline Alkaloids
- Alkaloids
- Pyrrole Alkaloids
Initial Source
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (24)

All WBCell Proliferation/Viability AssayCell Migration/Invasion AssayFlow CytometryIn Vivo Efficacy Study

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Journal Impact Factor

J Nanobiotechnology

An oral nanocombinatorial agent exhibits pleiotropic improvement in diabetic nephropathy via modulation of the SCAP/SREBPs pathway. [Abstract]

2026 Mar 22;24(1):405. PMID: 41866523
J Exp Clin Cancer Res

Cholesterol sensor SCAP contributes to sorafenib resistance by regulating autophagy in hepatocellular carcinoma. [Abstract]

2022 Mar 30;41(1):116. PMID: 35354475

Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]

Immunoblot analysis of SCAP protein expression at different concentrations. PLC-SR cells (control) were treated with Lycorine (Ly) (1, 2, 4 μM) alone, Sorafenib (Sora) alone or a combination of Lycorine and Sorafenib (Ly + Sora).

Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]

The combined use of Lycorine (1, 2, 4 μM) and Sorafenib significantly inhibited the proliferation of PLC-SR cells.

Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]

Lycorine (1, 2, 4 μM) combined with Sorafenib decelerated the migration and invasion of sorafenib-resistant HCC cells.

Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]

Flow cytometry analysis indicated that when Lycorine (1, 2, 4 μM) was combined with Sorafenib, the percentage of S phase cells was decreased, and apoptosis was significantly increased.

Lycorine hydrochloride purchased from MedChemExpress. Usage Cited in: J Exp Clin Cancer Res. 2022 Mar 30;41(1):116. [Abstract]

Lycorine (10 mg/kg, i.g.) combined with Sorafenib can reduce the tumor volume in mice.
Pharmacol Res

Lycorine improves peripheral nerve function by promoting Schwann cell autophagy via AMPK pathway activation and MMP9 downregulation in diabetic peripheral neuropathy. [Abstract]

2022 Jan:175:105985. PMID: 34863821
Int J Mol Med

Lycorine upregulates the expression of RMB10, promotes apoptosis and inhibits the proliferation and migration of cervical cancer cells. [Abstract]

2022 Dec;50(6):145. PMID: 36367172
Eur J Pharmacol

Lycorine eliminates B-cell acute lymphoblastic leukemia cells by targeting PSAT1 through the serine/glycine metabolic pathway. [Abstract]

2023 Dec 15:961:176162. PMID: 37951487
Int J Mol Sci

Lycorine Inhibits Influenza Virus Replication by Affecting Nascent Nucleoporin Nup93 Synthesis. [Abstract]

2025 Jun 3;26(11):5358. PMID: 40508167
Mol Med Rep

Excess phosphate promotes SARS‑CoV‑2 N protein‑induced NLRP3 inflammasome activation via the SCAP‑SREBP2 signaling pathway. [Abstract]

2024 Mar;29(3):48. PMID: 38275129
J Mol Cell Cardiol

Lycorine hydrochloride reveals a novel role in preventing neointimal hyperplasia through MAPK-mediated phenotypic switching of smooth muscle cells. [Abstract]

2026 Apr 28:S0022-2828(26)00059-3. PMID: 42061807
Cancers (Basel)

Lycorine hydrochloride Suppresses the Proliferation and Invasion of Esophageal Cancer by Targeting TRIM22 and Inhibiting the JAK2/STAT3 and Erk Pathways. [Abstract]

2025 Feb 20;17(5):718. PMID: 40075566
Microorganisms

Screening of Endophytic Bacteria of Leucojum aestivum 'Gravety Giant' as a Potential Source of Alkaloids and as Antagonist to Some Plant Fungal Pathogens. [Abstract]

2022 Oct 21;10(10):2089. PMID: 36296365
Antiviral Res

Discovery of hepatitis B virus subviral particle biogenesis inhibitors from a bioactive compound library. [Abstract]

2024 Aug:228:105955. PMID: 38964614
Pest Manag Sci

Functional analysis of down-regulated CYP6AE gene clusters involved in the insecticidal mechanism of lycorine against Spodoptera litura. [Abstract]

2026 Jun 20. PMID: 42322590
Vet Microbiol

The Chinese medicine monomer Schisandrin C inhibits PRRSV infection by regulating the OGT-PI3K/AKT/mTOR signaling pathway. [Abstract]

2026 May:316:110992. PMID: 41865607
J Nat Med

A plant alkaloid lycorine inhibits non-small cell lung cancer cell proliferation, metastasis, glycolysis and promotes ferroptosis through the ZNF143/SPC25 axis. [Abstract]

2026 Mar 9. PMID: 41801295
Ann Hematol

Lycorine inhibits the proliferation of acute myeloid leukemia cells by upregulating the expression of THBS1. [Abstract]

2026 Jan 17;105(1):24. PMID: 41545705
Ann Hematol

Lycorine induces apoptosis of acute myeloid leukemia cells and inhibits triglyceride production via binding and targeting FABP5. [Abstract]

2023 May;102(5):1073-1086. PMID: 36943465
Oncol Lett

Ferroptosis is involved in the anti-tumor effect of lycorine in renal cell carcinoma cells. [Abstract]

2021 Nov;22(5):781. PMID: 34594422
Mol Biol

2026 Jan 20.
SSRN

2025 Dec 19.
Preprints

2024 Nov.
bioRxiv

A pharmacological toolkit for human microglia identifies Topoisomerase I inhibitors as immunomodulators for Alzheimer's disease. [Abstract]

2024 Feb 6:2024.02.06.579103. PMID: 38370689
Patent

US20230014181.
Research Square Preprint

2022 Feb.
Research Square Preprint

2022 Jan.

Lösungsmittel & Löslichkeit

In Vitro:

DMSO : 25 mg/mL (77.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 16.67 mg/mL (51.49 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.0886 mL

15.4431 mL

30.8861 mL

5 mM

0.6177 mL

3.0886 mL

6.1772 mL

10 mM

0.3089 mL

1.5443 mL

3.0886 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

Stock Solution Working Solution

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline

Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)

Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil

Solubility: ≥ 2.08 mg/mL (6.42 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage Dosage
mg/kg
Animal Weight (Per Animal) Animal Weight (Per Animal)
g
Dosing Volume (Per Animal) Dosing Volume (Per Animal)
μL
Number of Animals Number of Animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Working solution concentration: 0.22 mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact

MedChemExpress (MCE) .

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (285 KB)
SDS (419 KB)
- English - EN (419 KB)
- Français - FR (419 KB)
- Deutsch - DE (419 KB)
- Norwegian - NO (419 KB)
- Español - ES (419 KB)
- Swedish - SV (419 KB)
- Italian - IT (419 KB)
- Korean - KR (419 KB)
- Portuguese - PT (419 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Liu, R. et al. Lycorine hydrochloride inhibits metastatic melanoma cell-dominant vasculogenic mimicry. Pigment cell & melanoma research 25, 630-638, doi:10.1111/j.1755-148X.2012.01036.x (2012). [Content Brief]

[2]. Cao, Z. et al.Lycorine hydrochloride selectively inhibits human ovarian cancer cell proliferation and tumor neovascularization with very low toxicity. Toxicology letters 218, 174-185, doi:10.1016/j.toxlet.2013.01.018 (2013). [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O / DMSO	1 mM	3.0886 mL	15.4431 mL	30.8861 mL	77.2153 mL
	5 mM	0.6177 mL	3.0886 mL	6.1772 mL	15.4431 mL
	10 mM	0.3089 mL	1.5443 mL	3.0886 mL	7.7215 mL
	15 mM	0.2059 mL	1.0295 mL	2.0591 mL	5.1477 mL
	20 mM	0.1544 mL	0.7722 mL	1.5443 mL	3.8608 mL
	25 mM	0.1235 mL	0.6177 mL	1.2354 mL	3.0886 mL
	30 mM	0.1030 mL	0.5148 mL	1.0295 mL	2.5738 mL
	40 mM	0.0772 mL	0.3861 mL	0.7722 mL	1.9304 mL
	50 mM	0.0618 mL	0.3089 mL	0.6177 mL	1.5443 mL
DMSO	60 mM	0.0515 mL	0.2574 mL	0.5148 mL	1.2869 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Bioz

Keywords

Lycorine hydrochloride

24 Cited Publications

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Lycorine hydrochloride

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