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Art. -Nr.: HY-163816

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Antiproliferative agent-53-d₃

Antiproliferative agent-53-d3 (Compound C1) is an inhibitor for theta-mediated end joining (TMEJ) in HEK293 cell with an IC₅₀ of 0.14 µM. Antiproliferative agent-53-d3 is the inhibitor for CYP2C19 and CYP2C9 with IC₅₀ of 0.77 and 3.1 µM. Antiproliferative agent-53-d3 inhibits the proliferation of DNA repair-compromised cells, with IC₅₀ of 8.1 µM for BRCA2^-/- DLD-1. Antiproliferative agent-53-d3 exhibits good pharmacokinetic characteristics in CD-1 mice.

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CAS. Nr.: 2923508-77-2
Formel: C₂₀H₁₄D₃ClF₄N₄O₂
Molecular Weight:459.84

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (273 KB)

Antiproliferative agent-53-d₃ Chemical Structure

CAS. Nr.: 2923508-77-2

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- Anwendung
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target

CYP2C19

0.77 μM (IC₅₀)

CYP2C9

3.1 μM (IC₅₀)

CYP3A4

14.6 μM (IC₅₀)

CYP2D6

17.3 μM (IC₅₀)

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
DLD-1	IC₅₀	8.1 μM Compound: C1	Antiproliferative activity against BRCA2 deficient human DLD-1 cells assessed as inhibition of cell growth incubated for 7 days by Cell-titer glo luminescence assay Antiproliferative activity against BRCA2 deficient human DLD-1 cells assessed as inhibition of cell growth incubated for 7 days by Cell-titer glo luminescence assay	[PMID: 38493730]

Anwendung

1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.

Chemical Information

CAS. Nr. 2923508-77-2
Molecular Weight 459.84
Formel C₂₀H₁₄D₃ClF₄N₄O₂
SMILES

[2H]C([2H])([2H])N(C1=CC(Cl)=C(C=C1)F)C([C@H]2N(C3=C(C(C(F)(F)F)=CC(C)=N3)C#N)C[C@H]2CO)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (273 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Wang Y, et al., Discovery of 3-hydroxymethyl-azetidine derivatives as potent polymerase theta inhibitors. Bioorg Med Chem. 2024 Apr 1;103:117662. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

Antiproliferative agent-53-d₃

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Anwendung
Chemical Information
Reinheit & Dokumentation
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Antiproliferative agent-53-d3

Alle Cytochrome P450 Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

Antiproliferative agent-53-d3 Related Classifications

HY-163816 Related Classifications

Antiproliferative agent-53-d₃

Antiproliferative agent-53-d₃ Related Classifications