COX-2-IN-51
COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin (HY-14397).
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- CAS. Nr.: 3064260-49-4
- Formel: C23H18F4O3S
- Molecular Weight:450.45
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Speicherung:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biologische Aktivität
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COX-2 70.7 nM (IC50) |
Chemical Information
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CAS. Nr. 3064260-49-4
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Molecular Weight 450.45
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Formel C23H18F4O3S
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SMILES
FC1=CC=C(OC(OCCC2=CSC=C2)(C(F)(F)F)C(C3=CC=C(OC)C=C3)=C4)C4=C1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Please store the product under the recommended conditions in the Certificate of Analysis.
Reinheit & Dokumentation
Verweise
Calculators
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
COX-2-IN-51 Related Classifications
HY-170585 Related Classifications
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