3064260-49-4
3064260-49-4
Chemical Structure
COX-2-IN-51
- CAS No.: 3064260-49-4
- Formula:C23H18F4O3S
- Molecular Weight:450.45
SMILES: FC1=CC=C(OC(OCCC2=CSC=C2)(C(F)(F)F)C(C3=CC=C(OC)C=C3)=C4)C4=C1
Biological Activity: COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin (HY-14397)[1].
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COX-2-IN-51 | COX-2-IN-51 (E25) is a potent COX-2 inhibitor, with an IC50 of 70.7 nM. COX-2-IN-51 significantly inhibits LPS-induced release of NO and PGE2, expression of COX-2 and iNOS, and activation of NF-κB pathway. COX-2-IN-51 exhibits anti-inflammatory and analgesic effects in diverse murine models through inhibiting NF-κB pathway. COX-2-IN-51 has lower gastrointestinal side effects than Indomethacin (HY-14397). | |||||||||||||||||||||
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References
Keywords
