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Art. -Nr.: HY-139874

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CXCR2 antagonist 3

CXCR2 antagonist 3 (compound 11h) is a potent antagonist of CXC chemokine receptor 2 (CXCR2). CXCR2 antagonist 3 demonstrates double-digit nanomolar potencies against CXCR2 and significantly inhibited neutrophil infiltration into the air pouch. CXCR2 antagonist 3 reduces the infiltration of neutrophils and MDSCs and enhance the infiltration of CD3⁺ T lymphocytes into the Pan02 tumor tissues.

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CAS. Nr.: 2647464-92-2
Formel: C₁₇H₁₅FN₂O₄S
Molecular Weight:362.38

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

CXCR2 antagonist 3 Chemical Structure

CAS. Nr.: 2647464-92-2

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Biologische Aktivität
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Biologische Aktivität

Beschreibung

Alle CXCR Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
BXPC-3	IC₅₀	>10 μM Compound: 11h	Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human BxPC3 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
MIA PaCa-2	IC₅₀	>10 μM Compound: 11h	Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human MIA PaCa-2 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
PANC-1	IC₅₀	>10 μM Compound: 11h	Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human PanC-1 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
PBMC	IC₅₀	>10 μM Compound: 11h	Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human PBMC cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]
SW1990	IC₅₀	>10 μM Compound: 11h	Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay Cytotoxicity against human SW1990 cells assessed as reduction in cell viability measured after 72 hrs by CCK8 assay	[PMID: 34676759]

Chemical Information

CAS. Nr. 2647464-92-2
Molecular Weight 362.38
Formel C₁₇H₁₅FN₂O₄S
SMILES

O=S1(C2=C(O)C(NC(NC3=CC=CC(F)=C3C)=O)=CC=C2C=CC1)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Dong Y, et al. Discovery of Benzocyclic Sulfone Derivatives as Potent CXCR2 Antagonists for Cancer Immunotherapy. J Med Chem. 2021;64(22):16626-16640. [Content Brief]

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Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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CXCR2 antagonist 3

Alle CXCR Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

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CXCR2 antagonist 3 Related Classifications

HY-139874 Related Classifications