TCFL5 - transcription factor like 5 Gene

Also Known as CHA; Figlb; SOSF1; E2BP-1; bHLHe82

Species: Homo sapiens

Gene Type: protein coding

Gene ID: 10732

About TCFL5

Cytogenetic location: 20q13.33 Genomic coordinates (GRCh38): 20:62,841,005-62,861,822 (from NCBI)

This gene has 2 transcripts (splice variants) and 173 orthologues. Broad expression in testis (RPKM 22.8), thyroid (RPKM 7.1) and 19 other tissues.

Summary

Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Involved in several processes, including negative regulation of transcription by RNA polymerase II; regulation of cell population proliferation; and spermatogenesis. Located in nucleus. [provided by Alliance of Genome Resources, Apr 2022]

TCFL5 Products (2)

mRNA	Protein	Name
NM_001301726.2	NP_001288655.1	transcription factor-like 5 protein isoform 2
NM_006602.4	NP_006593.2	transcription factor-like 5 protein isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Verweise	Source
enables DNA binding	IDA IDA: Inferred from direct assay	9763657	GOA
enables DNA-binding transcription repressor activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	12923186	GOA
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	12923186	GOA
enables sequence-specific double-stranded DNA binding	IDA IDA: Inferred from direct assay	28473536	GOA

Biological Process GO Annotation	Evidence	Verweise	Source
involved in negative regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	12923186	GOA
involved in regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	9763657	GOA
involved in regulation of cell differentiation	IEP IEP: Inferred from expression pattern	9763657	GOA
involved in regulation of cell population proliferation	IEP IEP: Inferred from expression pattern	9763657	GOA
involved in spermatogenesis	IEP IEP: Inferred from expression pattern	9763657	GOA

Cellular Component GO Annotation	Evidence	Verweise	Source
located in nucleus	IDA IDA: Inferred from direct assay	9763657	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

TCFL5 Protein Structure

HLH

0
100
200
300
400
500 a.a.

Protein Preferred Names	Protein Names
transcription factor-like 5 protein	HPV-16 E2-binding protein 1

Related Diseases

Diseases	Alias
Chagas Disease	American Trypanosomiasis Chagas' Disease Chagas' Disease With Digestive System Involvement Chagas' Disease With Nervous System Involvement Chagas' Disease With Other Organ Involvement Infection Due To Trypanosoma Cruzi South American Trypanosomiasis Chronic Chagas Disease With Digestive System Involvement
Bile Duct Cancer	Bile Duct Carcinoma Extrahepatic Bile Duct Carcinoma Carcinoma Of Extrahepatic Bile Duct Extrahepatic Bile Duct Cancer Bile Duct Neoplasms Bile Duct Tumor Ca Extrahepatic Bile Ducts Malignant Neoplasm Of The Extrahepatic Bile Duct Bile Duct Extrahepatic Carcinoma Malignant Tumor Of Extrahepatic Bile Duct
Gallbladder Adenocarcinoma	Adenocarcinoma Of The Gallbladder Carcinoma Of The Gallbladder
Mixed Germ Cell-Sex Cord Neoplasm	Mixed Germ Cell-Sex Cord-Stromal Tumor Mixed Germ Cell-Sex Cord Tumor
Trypanosomiasis
Volkmann Contracture	Ischemic Contracture Volkmann'S Ischemic Contracture
Gallbladder Cancer	Gallbladder Carcinoma Gallbladder Neoplasm Malignant Neoplasm Of Gallbladder Malignant Tumour Of Gallbladder Gallbladder Ca Localized Malignant Gallbladder Neoplasm Malignant Tumor Of The Gallbladder Tumor Of The Gallbladder Cancer Of The Gallbladder Carcinoma Gallbladder Carcinoma Of Gallbladder Gallbladder Neoplasms Malignant Neoplasm Of Gallbladder Localized Cancer Of Gallbladder Primary Malignant Neoplasm Of Gallbladder
Bile Duct Adenocarcinoma

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)

Art. -Nr.	Produktname	Wirkung	Reinheit	Rare Diseases
HY-RS14311	TCFL5 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21781	Tcfl5 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28298	Tcfl5 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Mus musculus	TCFL5	MGD	MGI:2672878
Macaca mulatta	TCFL5	VGNC	VGNC:98458
Felis catus	TCFL5	VGNC	VGNC:81236
Rattus norvegicus	TCFL5	RGD	RGD:1305899
Canis familiaris	TCFL5	VGNC	VGNC:49660
Others	TCFL5	NCBI