Pla2g2a - phospholipase A2, group IIA (platelets, synovial fluid) Gene

Also Known as EF; Mom1; Pla2; sPLA2; sPla2-IIA

Species: Mus musculus

Gene Type: protein coding
Gene ID: 18780

Summary

Proteins belonging to the Phospholipase A2 (PLA2) family hydrolyze Phospholipids into sn2 fatty acids and lysophospholipids. They function in a variety of cellular processes, including the digestion of Phospholipids and the production of molecules that induce inflammatory responses. This gene encodes a member of the group II class of secretory PLA2s. The secreted enzyme binds to heparin on the cell surface. Mutations in this gene increase the occurrence of intestinal polyps caused by a dominant mutation in the adenomatosis polyposis coli gene. A frameshift inactivates this gene product in some mouse strains including the strain of the reference genome, C57BL/6J, whereas a functional protein is produced in Other strains. [provided by RefSeq, Jul 2008]

Pla2g2a Products (1)

mRNA Protein Name
NM_001082531.1 NP_001076000.1 phospholipase A2, membrane associated precursor

Gene Ontology

  • Biological Process
Biological Process GO Annotation Evidence Verweise Source
acts upstream of cell population proliferation IGI
IGI: Inferred from genetic interaction
10451698 MGI
involved in defense response to Gram-positive bacterium IMP
IMP: Inferred from mutant phenotype
10358193 MGI
involved in intestinal stem cell homeostasis IMP
IMP: Inferred from mutant phenotype
27292189 MGI
NOT acts upstream of or within negative regulation of T cell proliferation IDA
IDA: Inferred from direct assay
19564598 MGI
acts upstream of or within negative regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10451698 MGI
acts upstream of or within negative regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
9288104 MGI
involved in prostaglandin biosynthetic process IDA
IDA: Inferred from direct assay
27292189 MGI
acts upstream of or within regulation of cell population proliferation IGI
IGI: Inferred from genetic interaction
10716720 MGI
acts upstream of or within regulation of endothelial cell proliferation IGI
IGI: Inferred from genetic interaction
9159163 MGI
acts upstream of or within regulation of epithelial cell proliferation IGI
IGI: Inferred from genetic interaction
8978062 MGI
acts upstream of or within somatic stem cell population maintenance IGI
IGI: Inferred from genetic interaction
1541640 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

phospholipase A2, membrane associated

  • GIIC sPLA2

  • enhancing factor

  • group IIA phospholipase A2

  • modifier of Min1

  • non-pancreatic secreted type II phospholipase A2

  • phosphatidylcholine 2-acylhydrolase 2A

  • secretory group II phospholipase A2

Recombinant Pla2g2a Proteins

Art. -Nr. Produktname Accession Reinheit
HY-P74628 PLA2G2A Protein, Mouse (P.pastoris, His) P31482 (N22-C146) ≥ 95%, as determined by reducing SDS-PAGE.

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS10621 PLA2G2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS17567 Pla2g2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24027 Pla2g2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pla2g2a NCBI NCBI:5320