LGR6 - leucine rich repeat containing G protein-coupled receptor 6 Gene

Also Known as GPCR; VTS20631

Species: Homo sapiens

Gene Type: protein coding
Gene ID: 59352

About LGR6

Cytogenetic location: 1q32.1 Genomic coordinates (GRCh38): 1:202,193,799-202,319,761 (from NCBI)

This gene has 8 transcripts (splice variants), 194 orthologues and 22 paralogues. Broad expression in gall bladder (RPKM 3.1), testis (RPKM 2.2) and 22 other tissues.

Summary

This gene encodes a member of the leucine-rich repeat-containing subgroup of the G protein-coupled 7-transmembrane protein superfamily. The encoded protein is a glycoprotein hormone receptor with a large N-terminal extracellular domain that contains leucine-rich repeats important for the formation of a horseshoe-shaped interaction motif for ligand binding. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]

LGR6 Products (3)

mRNA Protein Name
NM_001017403.2 NP_001017403.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform 1 precursor
NM_001017404.2 NP_001017404.1 leucine-rich repeat-containing G-protein coupled receptor 6 isoform 3
NM_021636.3 NP_067649.2 leucine-rich repeat-containing G-protein coupled receptor 6 isoform 2

Gene Ontology

  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Verweise Source
enables protein binding IPI
IPI: Inferred from physical interaction
21727895 GOA
Biological Process GO Annotation Evidence Verweise Source
involved in positive regulation of Wnt signaling pathway IDA
IDA: Inferred from direct assay
22615920 GOA
involved in positive regulation of cell migration IDA
IDA: Inferred from direct assay
22615920 GOA
Cellular Component GO Annotation Evidence Verweise Source
located in vesicle IDA
IDA: Inferred from direct assay
22615920 GOA
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

LGR6 Protein Structure

LRR_1

LRR_1: Leucine Rich Repeat (70 - 89)

LRR_8

LRR_8: Leucine rich repeat (92 - 150)

LRR_8

LRR_8: Leucine rich repeat (162 - 222)

LRR_1

LRR_1: Leucine Rich Repeat (235 - 253)

LRR_8

LRR_8: Leucine rich repeat (258 - 314)

(352 - 368)

LRR_8

LRR_8: Leucine rich repeat (375 - 434)

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (579 - 827)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 967 a.a.
Protein Preferred Names Protein Names

leucine-rich repeat-containing G-protein coupled receptor 6

  • gonadotropin receptor

LGR6 Antibodies

Art. -Nr. Produktname Anwendung Reactivity
HY-P82786 LGR6 Antibody (YA2531) WB, IHC-P, ICC/IF, FC Human, Mouse, Rat

Related Diseases

Diseases Alias
Myxedema
Hair Follicle Neoplasm

  • Hair Matrix Neoplasm

  • Hair Matrix Tumour
Ankyloglossia With Or Without Tooth Anomalies

  • Ankyloglossia

  • ANKG

  • 'Tongue-Tie'

  • Tongue-Tie

  • Tongue Tie

  • Aberrant Insertion Of Labial Frenulum

  • Aberrant Insertion Of Frenum Of Tongue

  • Short Frenulum Linguae

  • Short Frenulum Of Tongue
Ehlers-Danlos Syndrome, Spondylodysplastic Type, 3

  • Spondylocheirodysplasia, Ehlers-Danlos Syndrome-Like

  • Scd-Eds

  • EDSSPD3

  • Ehlers-Danlos Syndrome Spondylodysplastic Type 3

  • Ehlers-Danlos Syndrome, Spondylocheirodysplastic Type

  • Slc39a13-Related Spondylodysplastic Ehlers-Danlos Syndrome

  • Slc39a13-Related Speds

  • Slc39a13-Related Spondylodysplastic Eds

  • Spondylocheirodysplastic Ehlers-Danlos Syndrome

  • Speds-Slc39a13

  • Ehlers-Danlos Syndrome-Like Spondylocheirodysplasia

  • Ehlers-Danlos Syndrome, Spondylodysplastic, Type 3
Pilomatrixoma

  • Pilomatricoma

  • PTR

  • Epithelioma Calcificans Of Malherbe

  • Benign Pilomatricoma

  • Calcifying Epithelioma Of Malherbe

  • Pilomatricoma, Somatic

  • Benign Pilomatrixoma

  • Malherbe Calcifying Epithelioma
Premature Ovarian Failure 1

  • Ovarian Failure, Premature

  • Fmr1-Related Primary Ovarian Insufficiency

  • Fragile X-Associated Primary Ovarian Insufficiency

  • POF1

  • Pofx

  • Hypergonadotropic Ovarian Failure, X-Linked

  • Pof

  • Primary Ovarian Insufficiency, Fragile X-Associated

  • Primary Ovarian Insufficiency 1

  • Ovarian Failure Premature

  • Premature Ovarian Failure, X-Linked

  • Fragile X Premature Ovarian Failure

  • Fmr1-Related Premature Ovarian Failure

  • Familial Premature Ovarian Failure

  • Idiopathic Familial Premature Ovarian Failure

  • Fxpoi

  • X-Linked Hypergonadotropic Ovarian Failure

  • Hypergonadotropic Ovarian Failure X-Linked

  • Poi

  • Premature Ovarian Failure X-Linked

  • Primary Ovarian Insufficiency

  • Premature Ovarian Failure-1

  • Ovarian Failure, Premature, Type 1

  • Premature Ovarian Failure, Familial

  • Premature Menopause

  • Primary Hypogonadism

  • Turner Syndrome
Tetraamelia Syndrome

  • Tetra-Amelia Syndrome

  • Tetraamelia-Multiple Malformations Syndrome

  • Tetra-Amelia

  • Tetra-Amelia, Autosomal Recessive

  • Tetraamelia, Autosomal Recessive

  • Total Amelia

  • Zimmer Phocomelia

  • Tetams

  • Zimmer Taub Sova Syndrome
Ovarian Cancer

  • Ovarian Carcinoma

  • Ovarian Neoplasm

  • Malignant Tumour Of Ovary

  • Cancer Of The Ovary

  • Epithelial Ovarian Cancer

  • Neoplasm Of Ovary

  • Ovarian Neoplasms

  • Ovarian Cancers

  • Malignant Neoplasm Of Ovary

  • Primary Malignant Neoplasm Of Ovary

  • Ovarian Cancer, Somatic

  • Malignant Ovarian Tumor

  • Ovary Neoplasm

  • Primary Ovarian Cancer

  • Tumor Of The Ovary

  • Malignant Neoplasm Of The Ovary

  • Malignant Tumor Of The Ovary

  • Ovarian Malignant Tumor

  • OC

  • Ovarian Carcinomas

  • Cancer, Ovarian

  • Cancer Of Ovary

  • Ovary Cancer

  • Ca Ovary
Diseases Alias
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Related Agents

  • Pre-clinical Phase

Pre-clinical Phase

Bioactive Molecules (3)
Art. -Nr. Produktname
Wirkung
Reinheit
Rare Diseases
HY-RS07620 LGR6 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS21364 Lgr6 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27883 Lgr6 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Canis familiaris LGR6 VGNC VGNC:53617
Mus musculus LGR6 MGD MGI:2441805
Rattus norvegicus LGR6 RGD RGD:1560339
Others LGR6 NCBI