Art. -Nr.: HY-N0487

Glucosamine sulfate

(Synonyms: D-Glucosamine sulfate)

12 Cited Publications

Kundenbewertung

Based on 12 publication(s) in Google Scholar

Glucosamine sulfate (D-Glucosamine sulfate) is an amino sugar and a prominent precursor in the biochemical synthesis of glycosylated proteins and lipids, is used as a dietary supplement. Glucosamine sulfate also is a natural constituent of glycosaminoglycans in the cartilage matrix and synovial fluid, which when administered exogenously, exerts pharmacological effects on osteoarthritic cartilage and chondrocytes.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

Reinheit: 98.0%
CAS. Nr.: 29031-19-4
Formel: C₆H₁₅NO₉S
Molecular Weight:277.25

Speicherung:

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Glucosamine sulfate Chemical Structure

CAS. Nr.: 29031-19-4

Größe

Preis

Verfügbarkeit

Menge

Amount: USD 0.00

* Bitte wählen Sie Menge, bevor Sie Artikel hinzufügen.

Top Publications Citing

Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
Chemical Information
Publications (12)
Lösungsmittel & Löslichkeit
- In Vitro
- In Vivo
Reinheit & Dokumentation
Verweise
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

Human Endogenous Metabolite

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen :

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen :

In Vitro

Glucosamine sulfate (D-Glucosamine sulfate) exhibits dose-dependent DPPH antioxidant activity^[2].
Glucosamine sulfate treatment of Short-term (4 h) inhibits HIF-1α at the protein level, decreases phosphorylation of p70S6K and S6, translation-related proteins^[3].
Glucosamine sulfate significantly decreases renal expression of α-smooth muscle actin, collagen I, and fibronectin in the obstructed kidneys and TGF-β1-treated renal cells^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS. Nr. 29031-19-4
Appearance Solid
Molecular Weight 277.25
Formel C₆H₁₅NO₉S
Color White to off-white
SMILES

O=C[C@H](N)[C@H]([C@@H]([C@@H](CO)O)O)O.O=S(O)(O)=O
Synonyms

D-Glucosamine sulfate
Structure Classification
- Saccharides
Initial Source
- Endogenous metabolite
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

4°C, sealed storage, away from moisture

* In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Publications (12)

All Cell Proliferation/Viability AssayBio/Physico-chemical AssayWB

Sort by:

Journal Impact Factor

Nature

Lithocholic acid phenocopies anti-ageing effects of calorie restriction. [Abstract]

2025 Jul;643(8070):192-200. PMID: 39695227
Mil Med Res

Accelerating cartilage regeneration with DNA-SF hydrogel sustained release system-based cartilage organoids. [Abstract]

2025 Jul 28;12(1):39. PMID: 40722047
Theranostics

Endogenous glutamate determines ferroptosis sensitivity via ADCY10-dependent YAP suppression in lung adenocarcinoma. [Abstract]

2021 Mar 24;11(12):5650-5674. PMID: 33897873

Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]

LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). Cell death was measured after treatment for 24 h.

Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]

LUAD cells were treated with erastin with or without Fer-1 or DFO, in the presence or absence of GlcN (5 mM). MDA was measured after treatment for 16 h.

Glucosamine sulfate purchased from MedChemExpress. Usage Cited in: Theranostics. 2021 Mar 24;11(12):5650-5674. [Abstract]

Metabolites downstream of GFPT1 restore YAP alteration by erastin. p-YAP^S127, O-YAP^T241 and YAP were measured by IB in H1975 cells treated with or without erastin, glucose, GlcN (5 mM) or GlcNAc for 8 h.
Microbiome

Species-specific enhancement of enterohemorrhagic E. coli pathogenesis mediated by microbiome metabolites. [Abstract]

2019 Mar 20;7(1):43. PMID: 30890187
Cell Rep

The hexosamine biosynthetic pathway drives tumor immune evasion via translational control of PD-L1 at the elongation level. [Abstract]

2025 Sep 10;44(9):116249. PMID: 40938752
Artif Cells Nanomed Biotechnol

Characterization of genipin-crosslinked gelatin/PVA hydrogels and the chondroprotective influence of hydroxytyrosol: an In vitro study. [Abstract]

2026 Dec;54(1):248-275. PMID: 42331338
Int Immunopharmacol

Enhancing GFPT1 expression with glutamine protects chondrocytes in osteoarthritis. [Abstract]

2024 Oct 18;143(Pt 2):113427. PMID: 39426230
Diabetes Metab Syndr Obes

Establishment and Evaluation of HepG2 Cell Insulin Resistance Model. [Abstract]

2025 Jul 29:18:2573-2584. PMID: 40755745
Am J Physiol Gastrointest Liver Physiol

Glucose metabolism through the hexosamine biosynthetic pathway drives hepatic de novo lipogenesis via promoting N-linked protein glycosylation. [Abstract]

2025 Jun 1;328(6):G746-G759. PMID: 40331866
Biocell

2025 Sep 25;49(9):1711-1731.
bioRxiv

2026 Jan 26.
Laurea Magistrale in Biomedical Engineering, Politecnico di Milano

2019 Jun.

Lösungsmittel & Löslichkeit

In Vitro:

H₂O : 125 mg/mL (450.86 mM; Need ultrasonic)

View the Complete Stock Solution Preparation Table

Preparing Stock Solutions

View the Complete Stock Solution Preparation Table

Concentration Solvent Mass

1 mg

5 mg

10 mg

Concentration

Solvent

Mass

1 mM

3.6069 mL

18.0343 mL

36.0685 mL

5 mM

0.7214 mL

3.6069 mL

7.2137 mL

10 mM

0.3607 mL

1.8034 mL

3.6069 mL

Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.

Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

In Vivo:

Working Solution

For the following dissolution methods, please prepare the working solution directly:

It is recommended to prepare fresh solutions and use them promptly within a short period of time.

The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: PBS

Solubility: 100 mg/mL (360.69 mM); Clear solution; Need ultrasonic

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (279 KB)
SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Bruyère O, et al. Efficacy and safety of glucosamine sulfate in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016 Feb;45(4 Suppl):S12-7. [Content Brief]

[2]. Jamialahmadi K, et al. Protective effects of glucosamine hydrochloride against free radical-induced erythrocytes damage. Environ Toxicol Pharmacol. 2014 Jul;38(1):212-9. [Content Brief]

[3]. Jo JR, et al. Short-term treatment with glucosamine hydrochloride specifically downregulates hypoxia-inducible factor-1α at the protein level in YD-8 human tongue cancer cells. Int J Oncol. 2014 May;44(5):1699-706. [Content Brief]

[4]. Park J, et al. Glucosamine hydrochloride exerts a protective effect against unilateral ureteral obstruction-induced renal fibrosis by attenuating TGF-β signaling. J Mol Med (Berl). 2013 Nov;91(11):1273-84. [Content Brief]

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg
H₂O	1 mM	3.6069 mL	18.0343 mL	36.0685 mL	90.1713 mL
	5 mM	0.7214 mL	3.6069 mL	7.2137 mL	18.0343 mL
	10 mM	0.3607 mL	1.8034 mL	3.6069 mL	9.0171 mL
	15 mM	0.2405 mL	1.2023 mL	2.4046 mL	6.0114 mL
	20 mM	0.1803 mL	0.9017 mL	1.8034 mL	4.5086 mL
	25 mM	0.1443 mL	0.7214 mL	1.4427 mL	3.6069 mL
	30 mM	0.1202 mL	0.6011 mL	1.2023 mL	3.0057 mL
	40 mM	0.0902 mL	0.4509 mL	0.9017 mL	2.2543 mL
	50 mM	0.0721 mL	0.3607 mL	0.7214 mL	1.8034 mL
	60 mM	0.0601 mL	0.3006 mL	0.6011 mL	1.5029 mL
	80 mM	0.0451 mL	0.2254 mL	0.4509 mL	1.1271 mL
	100 mM	0.0361 mL	0.1803 mL	0.3607 mL	0.9017 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Keywords

Glucosamine sulfate

12 Cited Publications

100 mg Angebot einholen

Subscribe to the

MedChemExpress

Newsletter

Produktname:
Art. -Nr.:
Menge:
MCE Japan Authorized Agent:

Produktname:
CAS. Nr.:
Species:
Reinheit:
Menge:

Glucosamine sulfate

Reprogramming Compound Library

Oxygen Sensing Compound Library

NMPA-Approved Drug Library

Glutamine Metabolism Compound Library

FDA Approved & Pharmacopeial Drug Library

Anti-Breast Cancer Compound Library

Anti-Cancer Metabolism Compound Library

Angiogenesis-Related Compound Library

Transcription Factor-Targeted Library

Glucose Metabolism Compound Library

Food-Sourced Compound Library

Rare Diseases Drug Library

Pediatric Drug Library

Anti-Cancer Natural Product Library

FDA-Approved Anticancer Drug Library

Human Metabolite Library

Non-steroidal Anti-Inflammatory Compound Library

Anti-Aging Natural Product Library

Cancer Stem Cells Compound Library

Off-patent Drug Library

Metabolic Enzyme Compound Library

Animal-Sourced Natural Product Library

Cell Death Library

Anti-Ovarian Cancer Compound Library

Bioactive Compound Library Max

MCE Bioactive Compound Library

Natural Product Library Plus

Drug Repurposing Compound Library Plus

FDA-Approved Drug Library Plus

FDA-Approved Drug Library Mini

Bioactive Compound Library

Anti-Fibrosis Compound Library

Lactic Acid Metabolic Compound Library

High-Throughput Bioactive Compound Library

High-Throughput Natural Product Library

Mass Spectrometry Human Endogenous Metabolite Library

Mass Spectrometry Human Metabolite Library

Mouse Metabolite Compound Library

RNA Binding Bioactive Compound Library

Lactylation Compound Library

Mass Spectrometry Natural Product Library

Natural Product and Natural Product-Like Compound Library

Epigenetics Compound Library

Immunology/Inflammation Compound Library

Metabolism/Protease Compound Library

NF-κB Signaling Compound Library

Natural Product Library

FDA-Approved Drug Library

Anti-Cancer Compound Library

Autophagy Compound Library

Human Endogenous Metabolite Compound Library

Anti-Aging Compound Library

Drug Repurposing Compound Library

Publications Citing Use of MedChemExpress (MCE) Glucosamine sulfate

Alle Endogenous Metabolite Isoform-spezifische Produkte anzeigen

Alle HIF/HIF Prolyl-Hydroxylase Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Publications (12)

Lösungsmittel & Löslichkeit

Reinheit & Dokumentation

Verweise

Help & FAQs

Complete Stock Solution Preparation Table

Glucosamine sulfate Related Classifications

HY-N0487 Related Classifications