Guanine-13C
Based on 1 Customer Validation
Guanine-13C is the 13C labeled Guanine (HY-Y1055). Guanine is one of the fundamental components of nucleic acids (DNA and RNA). Guanine is a purine derivative, consisting of a fused pyrimidine-imidazole ring system with conjugated double bonds. Guanine has the potential to serve as a large-capacity N pool. Guanine has cytotoxic, antinociceptive and neuroprotective effects.
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- Reinheit: 99.5%
- CAS. Nr.: 201489-20-5
- Formel: C413CH5N5O
- Molecular Weight:152.12
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Speicherung:Powder -20°C, 3 years , 4°C, 2 years ; In solvent -80°C, 6 months , -20°C, 1 month
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Biologische Aktivität
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Chemical Information
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Lösungsmittel & Löslichkeit
- Reinheit & Dokumentation
- Verweise
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Help & FAQs
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Biologische Aktivität
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Human Endogenous Metabolite |
Microbial Metabolite |
Fungal Metabolite |
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
1. This compound can be used as a tracer
2. This compound can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Chemical Information
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CAS. Nr. 201489-20-5
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Unlabeled Cas 73-40-5
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Appearance Solid
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Molecular Weight 152.12
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Formel C413CH5N5O
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Color Light yellow to yellow
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SMILES
O=C1C2=C(N=[13CH]N2)NC(N)=N1
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Versand
Room temperature in continental US; may vary elsewhere.
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Speicherung
Powder -20°C 3 years 4°C 2 years In solvent -80°C 6 months -20°C 1 month
Lösungsmittel & Löslichkeit
1 M NaOH : 50 mg/mL (328.69 mM; Need ultrasonic)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
Konzentration (Stammlösung) × Volumen (Stammlösung) = Konzentration (Ziellösung) × Volumen (Ziellösung)
Reinheit & Dokumentation
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Data Sheet (273 KB)
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SDS (394 KB)
- English - EN (394 KB)
- Français - FR (394 KB)
- Deutsch - DE (394 KB)
- Norwegian - NO (394 KB)
- Español - ES (394 KB)
- Swedish - SV (394 KB)
- Italian - IT (394 KB)
- Korean - KR (394 KB)
- Portuguese - PT (394 KB)
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Handling Instructions (2659 KB)
Verweise
[1]. Mojzeš P, et al. Guanine, a high-capacity and rapid-turnover nitrogen reserve in microalgal cells. Proc Natl Acad Sci U S A. 2020 Dec 22;117(51):32722-32730. [Content Brief]
[2]. Chauhan V, et al. In Silico Discovery and Validation of Amide Based Small Molecule Targeting the Enzymatic Site of Shiga Toxin. J Med Chem. 2016 Dec 8;59(23):10763-10773. [Content Brief]
[3]. Messina E, et al. Guanine nucleotide depletion triggers cell cycle arrest and apoptosis in human neuroblastoma cell lines. Int J Cancer. 2004 Mar 1;108(6):812-7. [Content Brief]
[4]. de Oliveira ED, et al. Mechanisms involved in the antinociception induced by spinal administration of inosine or guanine in mice. Eur J Pharmacol. 2016 Feb 5;772:71-82. [Content Brief]
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| 1 M NaOH | 1 mM | 6.5738 mL | 32.8688 mL | 65.7376 mL | 164.3439 mL |
| 5 mM | 1.3148 mL | 6.5738 mL | 13.1475 mL | 32.8688 mL | |
| 10 mM | 0.6574 mL | 3.2869 mL | 6.5738 mL | 16.4344 mL | |
| 15 mM | 0.4383 mL | 2.1913 mL | 4.3825 mL | 10.9563 mL | |
| 20 mM | 0.3287 mL | 1.6434 mL | 3.2869 mL | 8.2172 mL | |
| 25 mM | 0.2630 mL | 1.3148 mL | 2.6295 mL | 6.5738 mL | |
| 30 mM | 0.2191 mL | 1.0956 mL | 2.1913 mL | 5.4781 mL | |
| 40 mM | 0.1643 mL | 0.8217 mL | 1.6434 mL | 4.1086 mL | |
| 50 mM | 0.1315 mL | 0.6574 mL | 1.3148 mL | 3.2869 mL | |
| 60 mM | 0.1096 mL | 0.5478 mL | 1.0956 mL | 2.7391 mL | |
| 80 mM | 0.0822 mL | 0.4109 mL | 0.8217 mL | 2.0543 mL | |
| 100 mM | 0.0657 mL | 0.3287 mL | 0.6574 mL | 1.6434 mL |
Guanine-13C Related Classifications
HY-Y1055S Related Classifications
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