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Art. -Nr.: HY-184424

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HDAC6-IN-84

HDAC6-IN-84 is a potent and selective HDAC6 inhibitor with an IC₅₀ of 25.56 nM and shows 478-fold selectivity over HDAC1. HDAC6-IN-84 increases α-tubulin acetylation and upregulates BDNF (exons I and IV) and other neurogenesis-related genes. HDAC6-IN-84 can be used for the study of Alzheimer’s disease (AD) and other neurodegenerative diseases.

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CAS. Nr.: 3053402-10-8
Formel: C₁₇H₁₆N₂O₃S
Molecular Weight:328.39

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

HDAC6-IN-84 Chemical Structure

CAS. Nr.: 3053402-10-8

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

HDAC6

25.56 nM (IC₅₀)

Alle HDAC Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
SH-SY5Y	IC50	40.8 μM	Shows low cytotoxicity in SH-SY5Y cells. Shows low cytotoxicity in SH-SY5Y cells.	42241502
HeLa	IC50	370 μM	Shows low cytotoxicity in HeLa cells. Shows low cytotoxicity in HeLa cells.	42241502

In Vitro

HDAC6-IN-84 (5h) inhibits HDAC6 with an IC₅₀ of 25.56 nM and shows 478-fold selectivity over HDAC1^[1].
HDAC6-IN-84 eliminates activity against HDAC2 and class IIa HDACs and further reduces activity against class I HDACs (HDAC1 and HDAC3)^[1].
HDAC6-IN-84 (0.3-3 μM; 24 h) promotes α-tubulin acetylation in SH-SY5Y and HeLa cells, while negligibly affecting histone H3 acetylation^[1].
HDAC6-IN-84 (0.1-10 μM; 24 h) shows low cytotoxicity in SH-SY5Y cells and HeLa cells.
HDAC6-IN-84 (1 μM) promotes neuronal gene activation and may enhance synaptic plasticity and development in human iPSC-derived NPCs^[1].
HDAC6-IN-84 (1 μM; 24-48 h) upregulates BDNF exons I, II, and IV in human iPSC-derived neural progenitor cells (NPCs)^[1].
HDAC6-IN-84 shows low inhibitory activities against CYP2C9, CYP2C19, CYP2D6, and CYP3A4 and exhibits low binding affinity to the hERG membrane channel, with an IC₅₀ of 159.1 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis^[1]

Cell Line:

SH-SY5Y cells, HeLa cells
Concentration:

0.3 μM, 1 μM, 3 μM
Incubation Time:

24 h
Result:

Promoted α-tubulin acetylation in a concentration-dependent manner while negligibly affecting histone H3 acetylation.
Selectively inhibited HDAC6 in the tested cells.

Cell Viability Assay^[1]

Cell Line:

SH-SY5Y cells, HeLa cells
Concentration:

0.1 μM, 0.3 μM, 1 μM, 3 μM, 10 μM
Incubation Time:

24 h
Result:

Showed low cytotoxicity in SH-SY5Y cells and HeLa cells.

RT-PCR^[1]

Cell Line:

human iPSC-derived NPCs
Concentration:

1 μM
Incubation Time:

24 h
Result:

Upregulated BDNF exons I, II, and IV.

In Vivo

HDAC6-IN-84 (5h) (0.015-0.15 mg/kg; i.p.; single administration) markedly recovers Scopolamine (HY-N0296)-induced memory impairment and restores step-through latency in mice^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:

Male 4-week-old ICR mice were treated with Scopolamine (HY-N0296) ( administered 30 min after compound treatment)^[1].
Dosage:

0.015 mg/kg, 0.05 mg/kg, 0.15 mg/kg
Administration:

Intraperitoneal injection (i.p.); single administration
Result:

For the 24 h-training session, no group differences in step-through latency were observed.
Markedly recovered the scopolamine-induced impairment and restored step-through latency.

Chemical Information

CAS. Nr. 3053402-10-8
Molecular Weight 328.39
Formel C₁₇H₁₆N₂O₃S
SMILES

O=C(NO)CCC1=CSC(C2=CC=C3C=C(OC)C=CC3=C2)=N1
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Nam G, et al. Thiazole-Linked N-Hydroxypropanamide Derivatives: Selective HDAC6 Inhibitors with Therapeutic Potential for Neurodegenerative Diseases. J Med Chem. 2026 Jun 25;69(12):14140-14155. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- In Vitro
- In Vivo
Chemical Information
Reinheit & Dokumentation
Verweise

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HDAC6-IN-84

Alle HDAC Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

HDAC6-IN-84 Related Classifications

HY-184424 Related Classifications