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Art. -Nr.: HY-184799

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sEH-IN-25

sEH-IN-25 is an orally active soluble epoxide hydrolase (epoxide hydrolase) inhibitor, with an IC₅₀ of 0.5 nM against human sEH and an IC₅₀ of 2 nM against rat sEH. sEH-IN-25 can be used in the research of cardiovascular diseases.

Nur für Forschungszwecke. Wir verkaufen nicht an Patienten.

CAS. Nr.: 1141896-04-9
Formel: C₁₉H₂₂BrF₃N₆O₂
Molecular Weight:503.32

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

sEH-IN-25 Chemical Structure

CAS. Nr.: 1141896-04-9

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Use of MCE Products

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- In Vitro
- Parmacokinetics
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

In Vitro

sEH-IN-25 potently inhibits soluble epoxide hydrolase activity in human embryonic kidney cells overexpressing human sEH with an IC₅₀ of 3 nM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Parmacokinetics

Species	Dose	Route	C_max	CL_plasma	T_1/2	V_dss	Bioavailability
Rat^[1]	2.0 mg/kg	i.v.	/	12 mL/min/kg	4.6 h	2.1 L/kg	100 %
Rat^[1]	0.2 mg/kg	p.o.	8 ng/mL	/	/	/	/
Rat^[1]	2.0 mg/kg	p.o.	112 ng/mL	/	/	/	/
Rat^[1]	20 mg/kg	p.o.	750 ng/mL	/	/	/	/

Chemical Information

CAS. Nr. 1141896-04-9
Molecular Weight 503.32
Formel C₁₉H₂₂BrF₃N₆O₂
SMILES

O=C(C1CCN(CC1)C2=NC(NC)=NC(C)=N2)NCC3=CC=C(C=C3OC(F)(F)F)Br
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Handling Instructions (2659 KB)

Verweise

[1]. Thalji RK, et al. Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase. Bioorganic & medicinal chemistry letters. 2013 Jun 15;23(12):3584-8. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Bioz

Keywords

MOQ

Minimum order quantity

100 mg

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