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Art. -Nr.: HY-12312A

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TCS 401 free base

2 Cited Publications

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Based on 2 publication(s) in Google Scholar

TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

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CAS. Nr.: 243967-42-2
Formel: C₁₀H₁₀N₂O₅S
Molecular Weight:270.26

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Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (270 KB)

TCS 401 free base Chemical Structure

CAS. Nr.: 243967-42-2

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Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

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Beschreibung

TCS 401 free base is a selective inhibitor of protein tyrosine phosphatase 1B (PTP1B).

Chemical Information

CAS. Nr. 243967-42-2
Molecular Weight 270.26
Formel C₁₀H₁₀N₂O₅S
SMILES

O=C(C(NC1=C(C(O)=O)C(CCNC2)=C2S1)=O)O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Publications (2)

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J Tissue Eng Regen Med

Inhibition of protein-tyrosine phosphatase 1B phosphorylation enhances early adhesion of mesenchymal stem cells to facilitate fabrication of tissue-engineered bone. [Abstract]

2020 Apr;14(4):575-587. PMID: 32061178

TCS 401 free base purchased from MedChemExpress. Usage Cited in: J Tissue Eng Regen Med. 2020 Apr;14(4):575-587. [Abstract]

The activation of Src by treatment with the 152RM peptide is reversed by pretreatment with the PTP1B inhibitor TCS-401, and the increased phosphorylation of β-catenin Y654 by treatment with the 152RM peptide is reduced by pretreatment with the Src inhibitor bosutinib.
In Vitro Cell Dev Biol Anim

Angiotensin II induces apoptosis of cardiac microvascular endothelial cells via regulating PTP1B/PI3K/Akt pathway. [Abstract]

2019 Dec;55(10):801-811. PMID: 31502193

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (270 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Du ZD, et al. Protein tyrosine phosphatase 1B regulates the activity of retinal pigment epithelial cells. Mol Vis. 2015 May 1;21:523-31. [Content Brief]

[2]. Ponnusamy M, et al. Necrotic renal epithelial cell inhibits renal interstitial fibroblast activation: role of protein tyrosine phosphatase 1B. Am J Physiol Renal Physiol. 2013 Mar 15;304(6):F698-709. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

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How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

Keywords

TCS 401 free base

2 Cited Publications

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TCS 401 free base purchased from MedChemExpress. Usage Cited in: J Tissue Eng Regen Med. 2020 Apr;14(4):575-587. [Abstract]

Customer Validation
The activation of Src by treatment with the 152RM peptide is reversed by pretreatment with the PTP1B inhibitor TCS-401, and the increased phosphorylation of β-catenin Y654 by treatment with the 152RM peptide is reduced by pretreatment with the Src inhibitor bosutinib.

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TCS 401 free base

Publications Citing Use of MedChemExpress (MCE) TCS 401 free base

Biologische Aktivität

Chemical Information

Publications (2)

Reinheit & Dokumentation

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TCS 401 free base Related Classifications

HY-12312A Related Classifications