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Art. -Nr.: HY-W794785

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WAY 208466

WAY 208466 is a selective 5-HT6 receptor agonist with an EC₅₀ of 7.3 nM. WAY-208466 increases GABA levels following both acute and chronic administration in the dorsolateral frontal cortex of rat models with stereotaxic surgery. WAY 208466 can be used for anxiety-related disorders like obsessive compulsive disorder (OCD) research.

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CAS. Nr.: 633304-27-5
Formel: C₁₇H₁₈FN₃O₂S
Molecular Weight:347.41

Speicherung:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

WAY 208466 Chemical Structure

CAS. Nr.: 633304-27-5

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Use of MCE Products

Fluorescent Dye

Strong Fluorescence Signal / Multi-Disciplinary Applications / High Fluorescence Specificity

Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
- Cellular Effect
Chemical Information
Reinheit & Dokumentation
Verweise
Calculators
Help & FAQs
Classifications
Bioz

Biologische Aktivität

Beschreibung

IC₅₀ & Target^[1]

5-HT₆ Receptor

7.3 nM (EC₅₀)

5-HT₇ Receptor

4764 nM (EC₅₀)

5-HT_2A Receptor

351 nM (EC₅₀)

5-HT_2B Receptor

313 nM (EC₅₀)

5-HT_2C (Ant) Rceptor

217 nM (EC₅₀)

5-HT_2C (Ago) Receptor

644 nM (EC₅₀)

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen :

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	IC₅₀	351 nM Compound: 10e, WAY-208466	Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells Displacement of [125I]DOI from human cloned 5HT2A receptor expressed in CHO cells	[PMID: 19523834]
CHO	IC₅₀	4764 nM Compound: 10e, WAY-208466	Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells Displacement of [3H]LSD from human cloned 5HT7 receptor expressed in CHO cells	[PMID: 19523834]
CHO	IC₅₀	644 nM Compound: 10e, WAY-208466	Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells Displacement of [3H]5-HT from human cloned 5HT2C receptor expressed in CHO cells	[PMID: 19523834]
CHO-K1	IC₅₀	>5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D4 receptor expressed in CHO-K1 cells	[PMID: 19523834]
CHO-K1	IC₅₀	<5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D2 receptor expressed in CHO-K1 cells	[PMID: 19523834]
CHO-K1	IC₅₀	>5000 nM Compound: 10e, WAY-208466	Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells Displacement of [3H]spiperone from human cloned dopamine D3 receptor expressed in CHO-K1 cells	[PMID: 19523834]
HeLa	EC₅₀	7.3 nM Compound: 10e, WAY-208466	Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA Agonist activity at human cloned 5HT6 receptor expressed in HeLa cells assessed as induction of adenylyl cyclase activity by RIA	[PMID: 19523834]
HeLa	EC₅₀	7.3 nM Compound: 3b	Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay Agonist activity at human HT6 receptor expressed in human HeLa cells assessed as intracellular cAMP level by radioimmunoassay	[PMID: 19884004]
HeLa	EC₅₀	7.3 nM Compound: 20, WAY-208466	Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay Agonist activity at human 5-HT6 receptor expressed in HeLa cells after 10 mins by scintillation proximity assay	[PMID: 26099069]

Chemical Information

CAS. Nr. 633304-27-5
Molecular Weight 347.41
Formel C₁₇H₁₈FN₃O₂S
SMILES

O=S(C1=CC(F)=CC=C1)(C2=CN(CCN(C)C)C3=C2C=CC=N3)=O
Versand

Room temperature in continental US; may vary elsewhere.
Speicherung

Please store the product under the recommended conditions in the Certificate of Analysis.

Reinheit & Dokumentation

Select Batch:

Reinheit: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

Verweise

[1]. Schechter LE, et al. Neuropharmacological profile of novel and selective 5-HT6 receptor agonists: WAY-181187 and WAY-208466. Neuropsychopharmacology. 2008 May;33(6):1323-35. [Content Brief]

Calculators

Molaritätsrechner

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass Mass

Konzentration Konzentration

Volumen Volumen

Molecular Weight Molecular Weight

Verdünnungsrechner

Konzentration _{(Stammlösung)} × Volumen _{(Stammlösung)} = Konzentration _{(Ziellösung)} × Volumen _{(Ziellösung)}

Konzentration _{(Stammlösung)} Konzentration _{(Stammlösung)}

Volumen _{(Stammlösung)} Volumen _{(Stammlösung)}

Konzentration _{(Ziellösung)} Konzentration _{(Ziellösung)}

Volumen _{(Ziellösung)} Volumen _{(Ziellösung)}

Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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MOQ

Minimum order quantity

100 mg

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Biologische Aktivität
- Beschreibung
- IC₅₀ & Target
Chemical Information
Reinheit & Dokumentation
Verweise

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WAY 208466

Alle 5-HT Receptor Isoform-spezifische Produkte anzeigen

Biologische Aktivität

Chemical Information

Reinheit & Dokumentation

Verweise

Calculators

Help & FAQs

WAY 208466 Related Classifications

HY-W794785 Related Classifications