1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines are 5-HT(6) receptor ligands

  • Bioorg Med Chem Lett. 2009 Dec 15;19(24):6935-8. doi: 10.1016/j.bmcl.2009.10.067.
Ronald C Bernotas  1 ,  Schuyler A Antane ,  Steven E Lenicek ,  Simon N Haydar ,  Albert J Robichaud ,  Boyd L Harrison ,  Guo Ming Zhang ,  Deborah Smith ,  Joseph Coupet ,  Lee E Schechter
Affiliations
  • 1. Chemical Sciences, Wyeth Research, 500 Arcola Road, Collegeville, PA 19426, USA. [email protected]
PMID: 19884004 DOI: 10.1016/j.bmcl.2009.10.067
Abstract

1-(2-Aminoethyl)-3-(arylsulfonyl)-1H-pyrrolopyridines were prepared. Binding assays indicated they are 5-HT(6) receptor ligands, among which 6f and 6g showed high affinity for 5-HT(6) receptors with K(i)=3.9 and 1.7 nM, respectively.