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Cat. No.: HY-175974

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Antitrypanosomal agent 27

Antitrypanosomal agent 27 (Compound 5c) is a quinazoline compound with antitrypanosomal activity. Antitrypanosomal agent 27 inhibits T.b. brucei with a GI₅₀ of 31 nM. Antitrypanosomal agent 27 can be used for the research of human african trypanosomiasis.

For research use only. We do not sell to patients.

CAS No.: 2148927-96-0
Formula: C₂₆H₂₃F₃N₆O₂
Molecular Weight:508.50

Storage:

Please store the product under the recommended conditions in the Certificate of Analysis.

Data Sheet (271 KB)

Antitrypanosomal agent 27 Chemical Structure

CAS No.: 2148927-96-0

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Biological Activity
- Description
- In Vitro
Chemical Information
Purity & Documentation
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Help & FAQs
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Biological Activity

Description

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In Vitro

Antitrypanosomal agent 27 shows the selectivity index ≥ 50 for human liver cancer HepG2 cells , and has no significant cytotoxicity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Chemical Information

CAS No. 2148927-96-0
Molecular Weight 508.50
Formula C₂₆H₂₃F₃N₆O₂
SMILES

CN1CCN(CC1)C2=CC=CC(C3=CC=C4N=CN=C(C4=C3)NC5=CC=C(C(C(F)(F)F)=C5)[N+]([O-])=O)=C2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Select Batch:

Purity: 99.98%

Assay: 99.98%

ee.: 99.98%

Data Sheet (271 KB)
COA (2659 KB)
Elemental Analysis Report (2659 KB)
HNMR (2659 KB)
CNMR (2659 KB)
RP-HPLC (2659 KB)
NP-HPLC (2659 KB)
MS (2659 KB)
LCMS (2659 KB)
IR (2659 KB)
GC (2659 KB)
OR (2659 KB)
SDS-PAGE (2659 KB)
SEC-HPLC (2659 KB)
Other Report (2659 KB)
Handling Instructions (2659 KB)

References

[1]. Spijkers-Shaw S, et al. Optimization of Quinazolines for Inhibition of Trypanosoma brucei Proliferation. ACS Med Chem Lett. 2025 Aug 22;16(9):1806-1813. [Content Brief]

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Help & FAQs

How should lyophilized recombinant proteins be reconstituted and stored?

1. Before opening the cap, centrifuge the vial at 13000 rpm for 20-30 seconds. This step will ensure that any lyophilized powder that may have adhered to the cap or walls is collected at the bottom of the vial, minimizing the risk of product loss.

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Biological Activity
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References

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Antitrypanosomal agent 27

All Parasite Isoforms

Biological Activity

Chemical Information

Purity & Documentation

References

Calculators

Help & FAQs

Antitrypanosomal agent 27 Related Classifications

HY-175974 Related Classifications