FLT3-IN-37
FLT3-IN-37 (Compound 6z) is a potent inhibitor of FLT3-ITD, with IC50 values of 1.5 and 3.4 nM for FLT3-ITD and TEL-VEGFR2, respectively. FLT3-IN-37 exhibits high selectivity for wild-type FLT3 (WT) and c-Kit. FLT3-IN-37 inhibits FLT3 phosphorylation and downregulates the expression of p-Akt, p-STAT5, and p-ERK. FLT3-IN-37 exerts anti-leukemia effects by blocking the cell cycle and inducing apoptosis (apoptosis). FLT3-IN-37 can be used for research on acute myeloid leukemia (AML).
For research use only. We do not sell to patients.
- Formula: C27H21ClF2N6O5
- Molecular Weight:582.94
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
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Biological Activity
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Chemical Information
- Purity & Documentation
- References
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Help & FAQs
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Biological Activity
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VEGFR2 3.4 nM (IC50) |
Chemical Information
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Molecular Weight 582.94
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Formula C27H21ClF2N6O5
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SMILES
CC1=CN(N=C(C1=O)C(NC2=CC=C(C(F)=C2)OC3=CC=NC(NC(N4CC(C4)O)=O)=C3)=O)C5=CC(Cl)=C(C=C5)F
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Shipping
Room temperature in continental US; may vary elsewhere.
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Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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